SYTL2

Synaptotagmin-like 2, also known as SYTL2, is a human gene.cite web | title = Entrez Gene: SYTL2 synaptotagmin-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54843| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: SYTL2 synaptotagmin-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54843| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nalefski EA, Falke JJ |title=The C2 domain calcium-binding motif: structural and functional diversity. |journal=Protein Sci. |volume=5 |issue= 12 |pages= 2375–90 |year= 1997 |pmid= 8976547 |doi=
*cite journal | author=Duncan RR, Shipston MJ, Chow RH |title=Double C2 protein. A review. |journal=Biochimie |volume=82 |issue= 5 |pages= 421–6 |year= 2000 |pmid= 10865129 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Nagase T, Kikuno R, Nakayama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=
*cite journal | author=Fukuda M, Mikoshiba K |title=Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1226–33 |year= 2001 |pmid= 11243866 |doi= 10.1006/bbrc.2001.4512
*cite journal | author=Fukuda M, Saegusa C, Mikoshiba K |title=Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 513–9 |year= 2001 |pmid= 11327731 |doi= 10.1006/bbrc.2001.4803
*cite journal | author=Craxton M |title=Genomic analysis of synaptotagmin genes. |journal=Genomics |volume=77 |issue= 1-2 |pages= 43–9 |year= 2001 |pmid= 11543631 |doi= 10.1006/geno.2001.6619
*cite journal | author=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9212–8 |year= 2002 |pmid= 11773082 |doi= 10.1074/jbc.M112414200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fukuda M |title=Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15390–6 |year= 2003 |pmid= 12590134 |doi= 10.1074/jbc.M213090200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Yu M, Kasai K, Nagashima K, "et al." |title=Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. |journal=Mol. Biol. Cell |volume=18 |issue= 2 |pages= 688–96 |year= 2007 |pmid= 17182843 |doi= 10.1091/mbc.E06-10-0914

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