XAF1

XIAP associated factor-1, also known as XAF1, is a human gene.cite web | title = Entrez Gene: XAF1 XIAP associated factor-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54739| accessdate = ]

PBB_Summary
section_title =
summary_text = X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001). [supplied by OMIM] cite web | title = Entrez Gene: XAF1 XIAP associated factor-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54739| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fong WG, Liston P, Rajcan-Separovic E, "et al." |title=Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. |journal=Genomics |volume=70 |issue= 1 |pages= 113–22 |year= 2001 |pmid= 11087668 |doi= 10.1006/geno.2000.6364
*cite journal | author=Liston P, Fong WG, Kelly NL, "et al." |title=Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. |journal=Nat. Cell Biol. |volume=3 |issue= 2 |pages= 128–33 |year= 2001 |pmid= 11175744 |doi= 10.1038/35055027
*cite journal | author=Leaman DW, Chawla-Sarkar M, Vyas K, "et al." |title=Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28504–11 |year= 2002 |pmid= 12029096 |doi= 10.1074/jbc.M204851200
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. |journal=Mol. Vis. |volume=8 |issue= |pages= 196–204 |year= 2002 |pmid= 12107411 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Byun DS, Cho K, Ryu BK, "et al." |title=Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. |journal=Cancer Res. |volume=63 |issue= 21 |pages= 7068–75 |year= 2004 |pmid= 14612497 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ng KC, Campos EI, Martinka M, Li G |title=XAF1 expression is significantly reduced in human melanoma. |journal=J. Invest. Dermatol. |volume=123 |issue= 6 |pages= 1127–34 |year= 2005 |pmid= 15610524 |doi= 10.1111/j.0022-202X.2004.23467.x
*cite journal | author=Wang J, He H, Yu L, "et al." |title=HSF1 down-regulates XAF1 through transcriptional regulation. |journal=J. Biol. Chem. |volume=281 |issue= 5 |pages= 2451–9 |year= 2006 |pmid= 16303760 |doi= 10.1074/jbc.M505890200
*cite journal | author=Yin W, Cheepala S, Clifford JL |title=Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1. |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue= 4 |pages= 1148–54 |year= 2006 |pmid= 16343440 |doi= 10.1016/j.bbrc.2005.11.128
*cite journal | author=Fang X, Liu Z, Fan Y, "et al." |title=Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor. |journal=Int. J. Cancer |volume=118 |issue= 10 |pages= 2485–9 |year= 2006 |pmid= 16353137 |doi= 10.1002/ijc.21636
*cite journal | author=Gilli F, Marnetto F, Caldano M, "et al." |title=Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1. |journal=Mult. Scler. |volume=12 |issue= 1 |pages= 47–57 |year= 2006 |pmid= 16459719 |doi=
*cite journal | author=Reu FJ, Bae SI, Cherkassky L, "et al." |title=Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. |journal=J. Clin. Oncol. |volume=24 |issue= 23 |pages= 3771–9 |year= 2006 |pmid= 16801630 |doi= 10.1200/JCO.2005.03.4074
*cite journal | author=Lee MG, Huh JS, Chung SK, "et al." |title=Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses. |journal=Oncogene |volume=25 |issue= 42 |pages= 5807–22 |year= 2006 |pmid= 16909101 |doi= 10.1038/sj.onc.1209867
*cite journal | author=Zou B, Chim CS, Zeng H, "et al." |title=Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. |journal=Gastroenterology |volume=131 |issue= 6 |pages= 1835–43 |year= 2007 |pmid= 17087954 |doi= 10.1053/j.gastro.2006.09.050
*cite journal | author=Micali OC, Cheung HH, Plenchette S, "et al." |title=Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta. |journal=BMC Cancer |volume=7 |issue= |pages= 52 |year= 2007 |pmid= 17376236 |doi= 10.1186/1471-2407-7-52
*cite journal | author=Kempkensteffen C, Hinz S, Schrader M, "et al." |title=Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome. |journal=Cancer Lett. |volume=254 |issue= 2 |pages= 227–35 |year= 2007 |pmid= 17449173 |doi= 10.1016/j.canlet.2007.03.006
*cite journal | author=Shibata T, Mahotka C, Wethkamp N, "et al." |title=Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas. |journal=Diagn. Mol. Pathol. |volume=16 |issue= 1 |pages= 1–8 |year= 2007 |pmid= 17471152 |doi= 10.1097/01.pdm.0000213471.92925.51
*cite journal | author=Chung SK, Lee MG, Ryu BK, "et al." |title=Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses. |journal=Gastroenterology |volume=132 |issue= 7 |pages= 2459–77 |year= 2007 |pmid= 17570219 |doi= 10.1053/j.gastro.2007.04.024
*cite journal | author=Arora V, Cheung HH, Plenchette S, "et al." |title=Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26202–9 |year= 2007 |pmid= 17613533 |doi= 10.1074/jbc.M700776200

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