Matt Kaeberlein

Dr. Matt Kaeberlein (born 1971^[1]) is an American biologist and biogerontologist best known for his research on evolutionarily conserved mechanisms of aging. He is currently at the University of Washington where he is a professor in the Department of Pathology.

While a graduate student in the laboratory of Leonard Guarente at the Massachusetts Institute of Technology, he discovered that increased activity of the Sir2 enzyme increases lifespan in the budding yeast.^[2]

Along with Preston Estep, Dr. Kaeberlein co-founded the human longevity research biotech company Longenity, Inc.^[3]

Dr. Kaeberlein was a post-doctoral fellow in the laboratory of Dr. Stanley Fields, where he carried out genome-wide screens for genes that regulate aging in yeast.^[4][5]

Along with Dr. Brian Kennedy, Kaeberlein has vocally questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins.^[6][7] Instead Kaeberlein and Kennedy have proposed that the caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase.^[4]

External links

• Kaeberlein Lab website
• Matt Kaeberlein faculty webpage

References

1. ^ WorldCat Identities file on Matt Kaeberlein
2. ^ Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-2580.
3. ^ Chen, I. (2002). Rookie rising. Sci Aging Knowledge Environ 2002, nf16.
4. ^ ^{a b} Kaeberlein, M., Powers, R.W., 3rd, Steffen, K.K., Westman, E.A., Hu, D., Dang, N., Kerr, E.O., Kirkland, K.T., Fields, S., and Kennedy, B.K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.
5. ^ Powers, R.W., 3rd, Kaeberlein, M., Caldwell, S.D., Kennedy, B.K., and Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20, 174-184.
6. ^ Kaeberlein, M., Kirkland, K.T., Fields, S., and Kennedy, B.K. (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2, E296.
7. ^ Kaeberlein, M., and Powers, R.W., 3rd (2007). Sir2 and calorie restriction in yeast: A skeptical perspective. Ageing Res Rev 6, 128-140.

Persondata
Name	Kaeberlein, Matt
Alternative names
Short description
Date of birth	1971
Place of birth
Date of death
Place of death