Brian K Kennedy

Brian K Kennedy

Brian K. Kennedy is an American biologist best known for his research on aging in yeast. He is currently a professor of Biochemistry at the University of Washington.

Along with Dr. Matt Kaeberlein and Dr. Stanley Fields, Dr. Kennedy has carried out genome-wide screens for aging genes in yeast. Dr. Kennedy has also vocally questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins [Kaeberlein, M., Kirkland, K.T., Fields, S., and Kennedy, B.K. (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2, E296.] . Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target or Rapamycin (TOR) kinase [Kaeberlein, M., Powers, R.W., 3rd, Steffen, K.K., Westman, E.A., Hu, D., Dang, N., Kerr, E.O., Kirkland, K.T., Fields, S., and Kennedy, B.K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.] .

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