CAV2

CAV2

Caveolin 2, also known as CAV2, is a human gene.cite web | title = Entrez Gene: CAV2 caveolin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=858| accessdate = ]

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.cite web | title = Entrez Gene: CAV2 caveolin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=858| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Engelman JA, Zhang X, Galbiati F, "et al." |title=Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1578–87 |year= 1999 |pmid= 9837809 |doi=
*cite journal | author=Glenney JR |title=The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. |journal=FEBS Lett. |volume=314 |issue= 1 |pages= 45–8 |year= 1992 |pmid= 1360410 |doi=
*cite journal | author=Murata M, Peränen J, Schreiner R, "et al." |title=VIP21/caveolin is a cholesterol-binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10339–43 |year= 1995 |pmid= 7479780 |doi=
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Scherer PE, Okamoto T, Chun M, "et al." |title=Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 131–5 |year= 1996 |pmid= 8552590 |doi=
*cite journal | author=Scherer PE, Lewis RY, Volonte D, "et al." |title=Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 46 |pages= 29337–46 |year= 1997 |pmid= 9361015 |doi=
*cite journal | author=Galbiati F, Volonte D, Gil O, "et al." |title=Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10257–62 |year= 1998 |pmid= 9707634 |doi=
*cite journal | author=Engelman JA, Zhang XL, Lisanti MP |title=Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. |journal=FEBS Lett. |volume=436 |issue= 3 |pages= 403–10 |year= 1998 |pmid= 9801158 |doi=
*cite journal | author=Fra AM, Mastroianni N, Mancini M, "et al." |title=Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors. |journal=Genomics |volume=56 |issue= 3 |pages= 355–6 |year= 1999 |pmid= 10087206 |doi= 10.1006/geno.1998.5723
*cite journal | author=Volonte D, Galbiati F, Li S, "et al." |title=Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12702–9 |year= 1999 |pmid= 10212252 |doi=
*cite journal | author=Engelman JA, Zhang XL, Lisanti MP |title=Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. |journal=FEBS Lett. |volume=448 |issue= 2-3 |pages= 221–30 |year= 1999 |pmid= 10218480 |doi=
*cite journal | author=Mora R, Bonilha VL, Marmorstein A, "et al." |title=Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25708–17 |year= 1999 |pmid= 10464308 |doi=
*cite journal | author=Fra AM, Pasqualetto E, Mancini M, Sitia R |title=Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2. |journal=Gene |volume=243 |issue= 1-2 |pages= 75–83 |year= 2000 |pmid= 10675615 |doi=
*cite journal | author=Schwab W, Kasper M, Gavlik JM, "et al." |title=Characterization of caveolins from human knee joint catilage: expression of caveolin-1, -2, and -3 in chondrocytes and association with integrin beta1. |journal=Histochem. Cell Biol. |volume=113 |issue= 3 |pages= 221–5 |year= 2000 |pmid= 10817676 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=de Marco MC, Kremer L, Albar JP, "et al." |title=BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 23009–17 |year= 2001 |pmid= 11294831 |doi= 10.1074/jbc.M009739200
*cite journal | author=Andoh A, Saotome T, Sato H, "et al." |title=Epithelial expression of caveolin-2, but not caveolin-1, is enhanced in the inflamed mucosa of patients with ulcerative colitis. |journal=Inflamm. Bowel Dis. |volume=7 |issue= 3 |pages= 210–4 |year= 2002 |pmid= 11515846 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398

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