Ionomycin

Ionomycin

chembox new
ImageFile=Ionomycin.svg
ImageSize=300
IUPACName=Calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22- [(2S,5S)-5- [(2R,5S)-5-(1-hydroxyethyl)-5-methyl-2-tetrahydrofuranyl] -5-methyl-2-tetrahydrofuranyl] -4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
OtherNames=
Section1=Chembox Identifiers
CASNo=56092-82-1
PubChem=6446270
SMILES=CC(CCC(=O) [O-] )CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O) [O-] . [Ca+2]
Section2=Chembox Properties
Formula=C41H70CaO9
MolarMass=747.0671
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3=Chembox Hazards
MainHazards=
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Ionomycin is an ionophore produced by the bacterium "Streptomyces conglobatus" [See [http://www.fermentek.co.il/ionomycin_CA_salt.htm Ionomycin Calcium salt] from Fermentek, manufacturer's product page for ionomycin] . It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes.It is also used to stimulate the intracellular production of the cytokines interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. These cytokines are important in the inflammatory response.

Commercially, Ionomycin can be obtained as a free acid, or as a Ca2+ salt.

References


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