NUPL1

Nucleoporin like 1
PDB rendering based on 2osz.
Available structures PDB 2osz
Identifiers
Symbols	NUPL1; KIAA0410; PRO2463
External IDs	OMIM: 607615 MGI: 1919094 HomoloGene: 40924 GeneCards: NUPL1 Gene
Gene Ontology Molecular function • nucleocytoplasmic transporter activity Cellular component • nucleus • nuclear envelope • nuclear envelope • nuclear pore • membrane • nuclear membrane Biological process • carbohydrate metabolic process • hexose transport • regulation of glucose transport • protein transport • glucose transport • viral reproduction • mRNA transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9818	71844
Ensembl	ENSG00000139496	ENSMUSG00000063895
UniProt	Q9BVL2	Q3UZQ6
RefSeq (mRNA)	NM_001008564.1	NM_170591.1
RefSeq (protein)	NP_001008564.1	NP_733479.1
Location (UCSC)	Chr 13: 25.88 – 25.92 Mb	Chr 14: 60.82 – 60.87 Mb
PubMed search	[1]	[2]

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.^[1][2]

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

References

1. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477. 
2. ^ ^{a b} "Entrez Gene: NUPL1 nucleoporin like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9818. 

Further reading

• Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120351. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199621. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.