DSCR2

Proteasome (prosome, macropain) assembly chaperone 1
Identifiers
Symbols	PSMG1; C21LRP; DSCR2; LRPC21; PAC1
External IDs	OMIM: 605296 MGI: 1860263 HomoloGene: 2759 GeneCards: PSMG1 Gene
Gene Ontology Molecular function • protein binding Cellular component • cytoplasm • endoplasmic reticulum Biological process • proteasome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8624	56088
Ensembl	ENSG00000183527	ENSMUSG00000022913
UniProt	O95456	n/a
RefSeq (mRNA)	NM_003720.2	NM_019537.2
RefSeq (protein)	NP_003711.1	NP_062410.1
Location (UCSC)	Chr 21: 40.55 – 40.56 Mb	Chr 16: 96.2 – 96.21 Mb
PubMed search	[1]	[2]

Proteasome assembly chaperone 1 is a protein that in humans is encoded by the PSMG1 gene.^[1][2][3]

References

1. ^ Vidal-Taboada JM, Lu A, Pique M, Pons G, Gil J, Oliva R (Jul 2000). "Down syndrome critical region gene 2: expression during mouse development and in human cell lines indicates a function related to cell proliferation". Biochem Biophys Res Commun 272 (1): 156–63. doi:10.1006/bbrc.2000.2726. PMID 10872820. 
2. ^ Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S (Dec 2006). "Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes". Mol Cell 24 (6): 977–84. doi:10.1016/j.molcel.2006.11.015. PMID 17189198. 
3. ^ "Entrez Gene: DSCR2 Down syndrome critical region gene 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8624. 

Further reading

• Vidal-Taboada JM, Sanz S, Egeo A, et al. (1998). "Identification and characterization of a new gene from human chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein.". Biochem. Biophys. Res. Commun. 250 (3): 547–54. doi:10.1006/bbrc.1998.9352. PMID 9784380. 
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Possik PA, Sommer CA, Issa Hori J, et al. (2005). "DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells.". European Journal of Histochemistry 48 (3): 267–72. PMID 15590417. 
• Vesa J, Brown Y, Greenfield D, Korenberg JR (2005). "Molecular and cellular characterization of the Down syndrome critical region protein 2.". Biochem. Biophys. Res. Commun. 328 (1): 235–42. doi:10.1016/j.bbrc.2004.09.226. PMID 15670775. 
• Hirano Y, Hendil KB, Yashiroda H, et al. (2005). "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.". Nature 437 (7063): 1381–5. doi:10.1038/nature04106. PMID 16251969.