DOT1L

DOT1-like, histone H3 methyltransferase (S. cerevisiae)
PDB rendering based on 1nw3.
Available structures PDB 1nw3
Identifiers
Symbols	DOT1L; DKFZp586P1823; DOT1; KIAA1814; KMT4
External IDs	OMIM: 607375 MGI: 2143886 HomoloGene: 32779 GeneCards: DOT1L Gene
EC number	2.1.1.43
Gene Ontology Molecular function • DNA binding • protein binding • methyltransferase activity • transferase activity • histone-lysine N-methyltransferase activity Cellular component • nucleus Biological process • chromatin modification • histone lysine methylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84444	208266
Ensembl	ENSG00000104885	ENSMUSG00000061589
UniProt	Q8TEK3	n/a
RefSeq (mRNA)	NM_032482	NM_199322.1
RefSeq (protein)	NP_115871	NP_955354.1
Location (UCSC)	Chr 19: 2.16 – 2.23 Mb	Chr 10: 80.22 – 80.26 Mb
PubMed search	[1]	[2]

DOT1-like, histone H3 methyltransferase (S. cerevisiae), also known as DOT1L, is a gene found in humans, as well as other eukaryotes.^[1]

References

1. ^ "Entrez Gene: DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84444. 

Further reading

• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906. 
• Feng Q, Wang H, Ng HH, et al. (2002). "Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.". Curr. Biol. 12 (12): 1052–8. doi:10.1016/S0960-9822(02)00901-6. PMID 12123582. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Min J, Feng Q, Li Z, et al. (2003). "Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase.". Cell 112 (5): 711–23. doi:10.1016/S0092-8674(03)00114-4. PMID 12628190. 
• Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Okada Y, Feng Q, Lin Y, et al. (2005). "hDOT1L links histone methylation to leukemogenesis.". Cell 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025. 
• Sistayanarain A, Tsuneyama K, Zheng H, et al. (2006). "Expression of Aurora-B kinase and phosphorylated histone H3 in hepatocellular carcinoma.". Anticancer Res. 26 (5A): 3585–93. PMID 17094487.