PCBD2

Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
Identifiers
Symbols	PCBD2; DCOH2; DCOHM; PHS2
External IDs	OMIM: 609836 MGI: 1919812 HomoloGene: 49987 GeneCards: PCBD2 Gene
EC number	4.2.1.96
Gene Ontology Molecular function • phenylalanine 4-monooxygenase activity • protein binding • 4-alpha-hydroxytetrahydrobiopterin dehydratase activity • lyase activity Cellular component • cellular_component • nucleus • mitochondrion Biological process • tetrahydrobiopterin biosynthetic process • positive regulation of transcription, DNA-dependent • protein homotetramerization • protein heterooligomerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84105	72562
Ensembl	ENSG00000132570	ENSMUSG00000021496
UniProt	Q9H0N5	Q9CZL5
RefSeq (mRNA)	NM_032151	NM_028281.1
RefSeq (protein)	NP_115527	NP_082557.1
Location (UCSC)	Chr 5: 134.24 – 134.34 Mb	Chr 13: 55.83 – 55.88 Mb
PubMed search	[1]	[2]

Pterin-4-alpha-carbinolamine dehydratase 2 is an enzyme that in humans is encoded by the PCBD2 gene.^[1][2][3]

References

1. ^ Rose RB, Pullen KE, Bayle JH, Crabtree GR, Alber T (Jun 2004). "Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2". Biochemistry 43 (23): 7345–55. doi:10.1021/bi049620t. PMID 15182178. 
2. ^ Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J Biol Chem 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910. 
3. ^ "Entrez Gene: PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84105. 

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311163. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Arias JM, Murbartián J, Perez-Reyes E (2003). "Cloning of a novel one-repeat calcium channel-like gene.". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Schaaf CP, Benzing J, Schmitt T, et al. (2005). "Novel interaction partners of the TPR/MET tyrosine kinase.". FASEB J. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.