PAAF1

Proteasomal ATPase-associated factor 1
Identifiers
Symbols	PAAF1; FLJ11848; PAAF; Rpn14; WDR71
External IDs	HomoloGene: 49821 GeneCards: PAAF1 Gene
Gene Ontology Molecular function • protein binding Cellular component • proteasome complex Biological process • interspecies interaction between organisms Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80227	n/a
Ensembl	ENSG00000175575	n/a
UniProt	Q9BRP4	n/a
RefSeq (mRNA)	NM_025155	n/a
RefSeq (protein)	NP_079431	n/a
Location (UCSC)	Chr 11: 73.59 – 73.64 Mb	n/a
PubMed search	[1]	n/a

Proteasomal ATPase-associated factor 1 is an enzyme that in humans is encoded by the PAAF1 gene.^[1][2][3][4]

Interactions

PAAF1 has been shown to interact with PSMD10.^[5]

References

1. ^ Park Y, Hwang YP, Lee JS, Seo SH, Yoon SK, Yoon JB (Apr 2005). "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases". Mol Cell Biol 25 (9): 3842–53. doi:10.1128/MCB.25.9.3842-3853.2005. PMC 1084299. PMID 15831487. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1084299. 
2. ^ Ponnappan S, Ovaa H, Ponnappan U (Mar 2007). "Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging". Int J Biochem Cell Biol 39 (4): 799–809. doi:10.1016/j.biocel.2007.01.002. PMID 17317272. 
3. ^ Lassot I, Latreille D, Rousset E, Sourisseau M, Linares LK, Chable-Bessia C, Coux O, Benkirane M, Kiernan RE (Feb 2007). "The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms". Mol Cell 25 (3): 369–83. doi:10.1016/j.molcel.2006.12.020. PMID 17289585. 
4. ^ "Entrez Gene: WDR71 WD repeat domain 71". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80227. 
5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.