DCDC2 (gene)

Doublecortin domain containing 2
PDB rendering based on 2dnf.
Available structures PDB 2dnf
Identifiers
Symbols	DCDC2; DCDC2A; RU2; RU2S
External IDs	OMIM: 605755 MGI: 2652818 HomoloGene: 9483 GeneCards: DCDC2 Gene
Gene Ontology Biological process • neuron migration • neuron migration • cellular defense response • nervous system development • intracellular signal transduction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51473	195208
Ensembl	ENSG00000146038	ENSMUSG00000035910
UniProt	Q9UHG0	Q5DU00
RefSeq (mRNA)	NM_001195610.1	NM_177577
RefSeq (protein)	NP_001182539.1	NP_808245
Location (UCSC)	Chr 6: 24.17 – 24.36 Mb	Chr 13: 25.15 – 25.3 Mb
PubMed search	[1]	[2]

Doublecortin domain-containing protein 2 is a protein that in humans is encoded by the DCDC2 gene.^[1][2][3]

This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Mutations in this gene have been associated with Reading Disability (RD), also referred to as developmental dyslexia.^[3]

References

1. ^ Van Den Eynde BJ, Gaugler B, Probst-Kepper M, Michaux L, Devuyst O, Lorge F, Weynants P, Boon T (Jan 2000). "A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription". J Exp Med 190 (12): 1793–800. doi:10.1084/jem.190.12.1793. PMC 2195717. PMID 10601354. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195717. 
2. ^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461. 
3. ^ ^{a b} "Entrez Gene: DCDC2 doublecortin domain containing 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51473. 

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Meng H, Smith SD, Hager K, et al. (2006). "DCDC2 is associated with reading disability and modulates neuronal development in the brain.". Proc. Natl. Acad. Sci. U.S.A. 102 (47): 17053–8. doi:10.1073/pnas.0508591102. PMC 1278934. PMID 16278297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1278934. 
• Schumacher J, Anthoni H, Dahdouh F, et al. (2006). "Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia.". Am. J. Hum. Genet. 78 (1): 52–62. doi:10.1086/498992. PMC 1380223. PMID 16385449. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1380223. 
• Brkanac Z, Chapman NH, Matsushita MM, et al. (2007). "Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 556–60. doi:10.1002/ajmg.b.30471. PMID 17450541.