PDE8A

Phosphodiesterase 8A
Rendering based on PDB 1LHQ.
Available structures PDB 1LHQ, 1LXX, 3ECM, 3ECN
Identifiers
Symbols	PDE8A; FLJ16150; HsT19550
External IDs	OMIM: 602972 MGI: 1277116 HomoloGene: 1957 GeneCards: PDE8A Gene
EC number	3.1.4.17
Gene Ontology Molecular function • two-component response regulator activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • phosphoric diester hydrolase activity • hydrolase activity • metal ion binding Cellular component • cellular_component • cytosol Biological process • regulation of transcription, DNA-dependent • cyclic nucleotide metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5151	18584
Ensembl	ENSG00000073417	ENSMUSG00000025584
UniProt	O60658	Q059P6
RefSeq (mRNA)	NM_002605.2	NM_008803.2
RefSeq (protein)	NP_002596.1	NP_032829.1
Location (UCSC)	Chr 15: 85.52 – 85.68 Mb	Chr 7: 88.36 – 88.48 Mb
PubMed search	[1]	[2]

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.^[1][2] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.^[3]

References

1. ^ Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252. 
2. ^ "Entrez Gene: PDE8A phosphodiesterase 8A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151. 
3. ^ Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF 3rd, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. PMID 21920574. 

Further reading

• Bass BL (2002). "RNA editing by adenosine deaminases that act on RNA.". Annu. Rev. Biochem. 71: 817–46. doi:10.1146/annurev.biochem.71.110601.135501. PMC 1823043. PMID 12045112. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1823043. 
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Glavas NA, Ostenson C, Schaefer JB, et al. (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. doi:10.1073/pnas.101131098. PMC 33466. PMID 11371644. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=33466. 
• Wang P, Wu P, Egan RW, Billah MM (2002). "Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution.". Gene 280 (1–2): 183–94. doi:10.1016/S0378-1119(01)00783-1. PMID 11738832. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–74. doi:10.1016/S0898-6568(02)00146-8. PMID 12681444. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Wu P, Wang P (2005). "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (51): 17634–9. doi:10.1073/pnas.0407649101. PMC 539753. PMID 15596729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=539753.