PCDH7

Protocadherin 7
Identifiers
Symbols	PCDH7; BH-Pcdh; BHPCDH; FLJ97161
External IDs	OMIM: 602988 MGI: 1860487 HomoloGene: 36101 GeneCards: PCDH7 Gene
Gene Ontology Molecular function • calcium ion binding Cellular component • plasma membrane • integral to plasma membrane Biological process • cell adhesion • homophilic cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5099	54216
Ensembl	ENSG00000169851	ENSMUSG00000029108
UniProt	O60245	n/a
RefSeq (mRNA)	NM_001173523.1	NM_018764
RefSeq (protein)	NP_001166994.1	NP_061234
Location (UCSC)	Chr 4: 30.72 – 31.14 Mb	Chr 5: 58.11 – 58.52 Mb
PubMed search	[1]	[2]

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.^[1][2]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.^[2]

References

1. ^ Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233. 
2. ^ ^{a b} "Entrez Gene: PCDH7 protocadherin 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5099. 

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169–80. PMID 10817752. 
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
• Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain.". FEBS Lett. 460 (1): 93–8. doi:10.1016/S0014-5793(99)01309-5. PMID 10571067. 
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16203. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.