OAS3

2'-5'-oligoadenylate synthetase 3, 100kDa
Identifiers
Symbols	OAS3; MGC133260; p100
External IDs	OMIM: 603351 MGI: 2180850 HomoloGene: 4510 GeneCards: OAS3 Gene
Gene Ontology Molecular function • nucleotide binding • RNA binding • ATP binding • transferase activity • nucleotidyltransferase activity Cellular component • microsome Biological process • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • immune response • cytokine-mediated signaling pathway • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4940	246727
Ensembl	ENSG00000111331	ENSMUSG00000032661
UniProt	Q9Y6K5	n/a
RefSeq (mRNA)	NM_006187.2	NM_145226.2
RefSeq (protein)	NP_006178.2	NP_660261.1
Location (UCSC)	Chr 12: 113.38 – 113.41 Mb	Chr 5: 121.2 – 121.23 Mb
PubMed search	[1]	[2]

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.^[1][2]

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.^[2]

References

1. ^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745. 
2. ^ ^{a b} "Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4940. 

Further reading

• Hovanessian AG, Justesen J (2007). "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.". Biochimie 89 (6-7): 779–88. doi:10.1016/j.biochi.2007.02.003. PMID 17408844. 
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818. 
• Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMC 553929. PMID 2440675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=553929. 
• Marié I, Blanco J, Rebouillat D, Hovanessian AG (1997). "69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters.". Eur. J. Biochem. 248 (2): 558–66. doi:10.1111/j.1432-1033.1997.t01-1-00558.x. PMID 9346316. 
• Rebouillat D, Hovnanian A, Marié I, Hovanessian AG (1999). "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains.". J. Biol. Chem. 274 (3): 1557–65. doi:10.1074/jbc.274.3.1557. PMID 9880533. 
• Rebouillat D, Hovnanian A, David G, et al. (2001). "Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase.". Genomics 70 (2): 232–40. doi:10.1006/geno.2000.6382. PMID 11112351. 
• Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells.". Cancer Res. 61 (5): 2038–46. PMID 11280764. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.