James Hughes (disambiguation)
- James Hughes (disambiguation)
James Hughes is an American sociologist and bioethicist.
James Hughes may also refer to:
* James Hughes (politician) (died 1845), British Member of Parliament for Grantham
* James B. Hughes (1805–1873), American newspaper publisher, state legislator for Ohio
* James Madison Hughes, (1809–1861), U.S. Representative from Missouri
* James Hughes (representative) (1823–1873), U.S. Representative from Indiana
* James Joseph Hughes (1856–1941), Canadian Senator and Member of Parliament
* James A. Hughes (1861–1930), U.S. Representative from West Virginia
* James H. Hughes (1867–1953), American lawyer and politician, U.S. Senator from Delaware
* James F. Hughes, (1883–1940), U.S. Representative from Wisconsin
* Jimmy Hughes (1909–1966), English footballer
* Jim Hughes (1923–2001), American baseball pitcher
* Jim Hughes (pitcher born 1951), American baseball pitcher for the Minnesota Twins
* Jim Hughes, British punk/New Wave bassist who formed part of 1970s and 1980s bands The Banned and Cowboys International
* James Hughes (boxer) (1965–1995), American flyweight boxer
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