Rosenthal fiber

Rosenthal fiber

A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders. Its presence is pathognomonic of either pilocytic astrocytoma (more common) or Alexander's disease (a rare leukodystrophy). The fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins.

=References=
* Neuropathology Mini-Course. [http://www.pathology.vcu.edu/WirSelfInst/tumor-2.html Chapter 9 - Tumors of the Nervous System]
* [http://www.thedoctorsdoctor.com/bodysites/brainandspinalcord.htm Doctor's Doctor - Brain and Spinal Cord]
* [http://ajp.amjpathol.org/cgi/content/abstract/130/3/569 Isolation of a major protein component of Rosenthal fibers]


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