OSTalpha

Organic solute transporter alpha
Identifiers
Symbols	OSTalpha; MGC39807; OSTA
External IDs	OMIM: 612084 MGI: 2146634 HomoloGene: 44941 GeneCards: OSTalpha Gene
Gene Ontology Molecular function • transporter activity Cellular component • plasma membrane • integral to membrane Biological process • transport • transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	200931	106407
Ensembl	ENSG00000163959	ENSMUSG00000035699
UniProt	Q86UW1	Q8R000
RefSeq (mRNA)	NM_152672	NM_145932.3
RefSeq (protein)	NP_689885	NP_666044.1
Location (UCSC)	Chr 3: 195.94 – 195.97 Mb	Chr 16: 32.48 – 32.49 Mb
PubMed search	[1]	[2]

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.^[1][2]

Function

OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.^[2][3] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.^[3] The heterodimer furthermore is essential for intestinal bile acid transport.^[4]

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.^[2]

References

1. ^ "Entrez Gene: OSTalpha organic solute transporter alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200931. 
2. ^ ^{a b c} Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432. 
3. ^ ^{a b} Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1224727. 
4. ^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. doi:10.1073/pnas.0712328105. PMC 2268840. PMID 18292224. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2268840. 

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Seward DJ, Koh AS, Boyer JL, Ballatori N (2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432. 
• Dawson PA, Hubbert M, Haywood J, et al. (2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1224727. 
• Lee H, Zhang Y, Lee FY, et al. (2006). "FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine". J. Lipid Res. 47 (1): 201–14. doi:10.1194/jlr.M500417-JLR200. PMID 16251721. 
• Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA (2006). "The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G476–85. doi:10.1152/ajpgi.00430.2005. PMID 16269519. 
• Ballatori N, Christian WV, Lee JY, et al. (2005). "OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia". Hepatology 42 (6): 1270–9. doi:10.1002/hep.20961. PMID 16317684. 
• Boyer JL, Trauner M, Mennone A, et al. (2006). "Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (6): G1124–30. doi:10.1152/ajpgi.00539.2005. PMID 16423920. 
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Sun AQ, Balasubramaniyan N, Xu K, et al. (2007). "Protein-protein interactions and membrane localization of the human organic solute transporter". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (6): G1586–93. doi:10.1152/ajpgi.00457.2006. PMID 17332473.