WARS2

Tryptophanyl tRNA synthetase 2, mitochondrial, also known as WARS2, is a human gene.cite web | title = Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10352| accessdate = ]

PBB_Summary
section_title =
summary_text = Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.cite web | title = Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10352| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL |title=Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3-->p13.1 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 249–50 |year= 1999 |pmid= 10072595 |doi=
*cite journal | author=Jorgensen R, Søgaard TM, Rossing AB, "et al." |title=Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16820–6 |year= 2000 |pmid= 10828066 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu J, Shue E, Ewalt KL, Schimmel P |title=A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase. |journal=Nucleic Acids Res. |volume=32 |issue= 2 |pages= 719–27 |year= 2004 |pmid= 14757836 |doi= 10.1093/nar/gkh240
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Guo LT, Chen XL, Zhao BT, "et al." |title=Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311. |journal=Nucleic Acids Res. |volume=35 |issue= 17 |pages= 5934–43 |year= 2007 |pmid= 17726052 |doi= 10.1093/nar/gkm633

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