- GAS2
Growth arrest-specific 2, also known as GAS2, is a human
gene .cite web | title = Entrez Gene: GAS2 growth arrest-specific 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2620| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.cite web | title = Entrez Gene: GAS2 growth arrest-specific 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2620| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Olson RE, Morello JA, Kieff ED |title=Antibiotic treatment of oral anaerobic infections. |journal=Journal of oral surgery (American Dental Association : 1965) |volume=33 |issue= 8 |pages= 619–21 |year= 1975 |pmid= 1056466 |doi=
*cite journal | author=Brancolini C, Bottega S, Schneider C |title=Gas2, a growth arrest-specific protein, is a component of the microfilament network system. |journal=J. Cell Biol. |volume=117 |issue= 6 |pages= 1251–61 |year= 1992 |pmid= 1607387 |doi=
*cite journal | author=Schneider C, King RM, Philipson L |title=Genes specifically expressed at growth arrest of mammalian cells. |journal=Cell |volume=54 |issue= 6 |pages= 787–93 |year= 1988 |pmid= 3409319 |doi=
*cite journal | author=Collavin L, Buzzai M, Saccone S, "et al." |title=cDNA characterization and chromosome mapping of the human GAS2 gene. |journal=Genomics |volume=48 |issue= 2 |pages= 265–9 |year= 1998 |pmid= 9521882 |doi= 10.1006/geno.1997.5172
*cite journal | author=Sgorbissa A, Benetti R, Marzinotto S, "et al." |title=Caspase-3 and caspase-7 but not caspase-6 cleave Gas2 in vitro: implications for microfilament reorganization during apoptosis. |journal=J. Cell. Sci. |volume=112 ( Pt 23) |issue= |pages= 4475–82 |year= 2000 |pmid= 10564664 |doi=
*cite journal | author=Benetti R, Del Sal G, Monte M, "et al." |title=The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis. |journal=EMBO J. |volume=20 |issue= 11 |pages= 2702–14 |year= 2001 |pmid= 11387205 |doi= 10.1093/emboj/20.11.2702
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tsutsumi S, Kamata N, Vokes TJ, "et al." |title=The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1255–61 |year= 2004 |pmid= 15124103 |doi= 10.1086/421527
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Benetti R, Copetti T, Dell'Orso S, "et al." |title=The calpain system is involved in the constitutive regulation of beta-catenin signaling functions. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22070–80 |year= 2005 |pmid= 15817486 |doi= 10.1074/jbc.M501810200PBB_Controls
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