PDS5B

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
Identifiers
Symbols	PDS5B; APRIN; AS3; CG008; FLJ23236; KIAA0979
External IDs	OMIM: 605333 MGI: 2140945 HomoloGene: 41001 GeneCards: PDS5B Gene
Gene Ontology Molecular function • DNA binding • protein binding • ATP binding • identical protein binding Cellular component • chromatin • nucleus Biological process • cell cycle • mitotic sister chromatid cohesion • mitosis • cell proliferation • negative regulation of cell proliferation • regulation of cell proliferation • cell division Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23047	100710
Ensembl	ENSG00000083642	ENSMUSG00000034021
UniProt	Q9NTI5	n/a
RefSeq (mRNA)	NM_015032	NM_175310.6
RefSeq (protein)	NP_055847	NP_780519.3
Location (UCSC)	Chr 13: 33.16 – 33.35 Mb	Chr 5: 151.48 – 151.61 Mb
PubMed search	[1]	[2]

Sister chromatid cohesion protein PDS5 homolog B is a protein that in humans is encoded by the PDS5B gene.^[1][2][3]

References

1. ^ Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J, et al. (Feb 1997). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics 36 (1): 86–99. doi:10.1006/geno.1996.0428. PMID 8812419. 
2. ^ Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM (May 1999). "Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus". J Steroid Biochem Mol Biol 68 (1–2): 41–50. doi:10.1016/S0960-0760(98)00165-4. PMID 10215036. 
3. ^ "Entrez Gene: APRIN androgen-induced proliferation inhibitor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23047. 

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
• Geck P, Maffini MV, Szelei J, et al. (2000). "Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10185–90. doi:10.1073/pnas.97.18.10185. PMC 27796. PMID 10963680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27796. 
• Maffini MV, Geck P, Powell CE, et al. (2002). "Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate". Endocrinology 143 (7): 2708–14. doi:10.1210/en.143.7.2708. PMID 12072405. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747. 
• Rankin S, Ayad NG, Kirschner MW (2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol. Cell 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422. 
• Losada A, Yokochi T, Hirano T (2006). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J. Cell. Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.