DYX1C1

Dyslexia susceptibility 1 candidate 1
Identifiers
Symbols	DYX1C1; DYX1; DYXC1; EKN1; FLJ37882; MGC70618; RD
External IDs	OMIM: 608706 MGI: 1914935 HomoloGene: 12173 GeneCards: DYX1C1 Gene
Gene Ontology Molecular function • protein binding • estrogen receptor binding Cellular component • nucleus • cytoplasm Biological process • neuron migration • nervous system development • regulation of estrogen receptor signaling pathway • regulation of proteasomal protein catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	161582	67685
Ensembl	ENSG00000256061	ENSMUSG00000089865
UniProt	Q8WXU2	Q5VJS4
RefSeq (mRNA)	NM_001033559.2	NM_026314
RefSeq (protein)	NP_001028731.1	NP_080590
Location (UCSC)	Chr 15: 55.65 – 55.8 Mb	Chr 9: 72.81 – 72.86 Mb
PubMed search	[1]	[2]

Dyslexia susceptibility 1 candidate gene 1 protein is a protein that in humans is encoded by the DYX1C1 gene.^[1][2] This protein contains 420-amino acids with 3 tetratricopeptide repeat (TPR) domains, thought to mediate protein–protein interactions.

Clinical significance

A mutation in the DYX1C1 gene has been associated with deficits in reading ability (dyslexia).^[1][3]

References

1. ^ ^{a b} Taipale M, Kaminen N, Nopola-Hemmi J, Haltia T, Myllyluoma B, Lyytinen H, Muller K, Kaaranen M, Lindsberg PJ, Hannula-Jouppi K, Kere J (Oct 2003). "A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain". Proc Natl Acad Sci U S A 100 (20): 11553–8. doi:10.1073/pnas.1833911100. PMC 208796. PMID 12954984. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=208796. 
2. ^ "Entrez Gene: DYX1C1 dyslexia susceptibility 1 candidate 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=161582. 
3. ^ Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ (November 2009). "Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation". Mol. Psychiatry 15 (12): 1190–6. doi:10.1038/mp.2009.120. PMID 19901951. 

Further reading

• Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, Wright MJ (November 2009). "Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation". Mol. Psychiatry 15 (12): 1190–6. doi:10.1038/mp.2009.120. PMID 19901951. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Brkanac Z, Chapman NH, Matsushita MM, et al. (2007). "Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 556–60. doi:10.1002/ajmg.b.30471. PMID 17450541. 
• Cope NA, Hill G, van den Bree M, et al. (2005). "No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia.". Mol. Psychiatry 10 (3): 237–8. doi:10.1038/sj.mp.4001596. PMID 15477871. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Marino C, Citterio A, Giorda R, et al. (2007). "Association of short-term memory with a variant within DYX1C1 in developmental dyslexia.". Genes, Brain and Behavior 6 (7): 640–6. doi:10.1111/j.1601-183X.2006.00291.x. PMID 17309662. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Scerri TS, Fisher SE, Francks C, et al. (2005). "Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK.". J. Med. Genet. 41 (11): 853–7. doi:10.1136/jmg.2004.018341. PMC 1735619. PMID 15520411. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1735619. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wigg KG, Couto JM, Feng Y, et al. (2005). "Support for EKN1 as the susceptibility locus for dyslexia on 15q21.". Mol. Psychiatry 9 (12): 1111–21. doi:10.1038/sj.mp.4001543. PMID 15249932. 
• Ylisaukko-Oja T, Peyrard-Janvid M, Lindgren CM, et al. (2005). "Family-based association study of DYX1C1 variants in autism.". Eur. J. Hum. Genet. 13 (1): 127–30. doi:10.1038/sj.ejhg.5201272. PMID 15470369. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Dyslexia research Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу PRUNE2 Tornado (Särkänniemi roller coaster) Look at other dictionaries: Dyslexia — This article is about developmental dyslexia. For acquired dyslexia, see Alexia (acquired dyslexia). Dyslexia Classification and external resources ICD 10 R48.0 ICD 9 …   Wikipedia DYX1 — Dyslexia susceptibility 1 Identifiers Symbols DYX1; RD External IDs OMIM:  …   Wikipedia Dislexie — Dyslexie La dyslexie est la difficulté d identification des mots écrits, difficulté qui entraîne des problèmes d écriture parfois qualifiés indépendamment de dysgraphie et de dysorthographie. Dans le langage courant comme dans le langage médical …   Wikipédia en Français Dyslexie — Classification et ressources externes CIM 10 R48.0 CIM 9 315.02 OMIM …   Wikipédia en Français Dyslexique — Dyslexie La dyslexie est la difficulté d identification des mots écrits, difficulté qui entraîne des problèmes d écriture parfois qualifiés indépendamment de dysgraphie et de dysorthographie. Dans le langage courant comme dans le langage médical …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”