DDX19B

DEAD (Asp-Glu-Ala-As) box polypeptide 19B
Rendering based on PDB 3EWS.
Available structures PDB 3EWS, 3FHC, 3FHT, 3FMO, 3FMP, 3G0H
Identifiers
Symbols	DDX19B; DBP5; DDX19; RNAh
External IDs	OMIM: 605812 MGI: 2148251 HomoloGene: 56032 GeneCards: DDX19B Gene
EC number	3.6.4.13
Gene Ontology Molecular function • nucleotide binding • RNA binding • helicase activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity Cellular component • nucleus • nuclear pore • cytoplasm • membrane • nuclear membrane Biological process • mRNA export from nucleus • protein transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11269	234733
Ensembl	ENSG00000157349	ENSMUSG00000033658
UniProt	Q9UMR2	n/a
RefSeq (mRNA)	NM_001014449.1	XM_001001084
RefSeq (protein)	NP_001014449.1	XP_001001084
Location (UCSC)	Chr 16: 70.33 – 70.37 Mb	Chr 8: 113.51 – 113.56 Mb
PubMed search	[1]	[2]

ATP-dependent RNA helicase DDX19B is an enzyme that in humans is encoded by the DDX19B gene.^[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which exhibits RNA-dependent ATPase and ATP-dependent RNA-unwinding activities. This protein is recruited to the cytoplasmic fibrils of the nuclear pore complex, where it participates in the export of mRNA from the nucleus. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[2]

References

1. ^ Schmitt C, von Kobbe C, Bachi A, Pante N, Rodrigues JP, Boscheron C, Rigaut G, Wilm M, Seraphin B, Carmo-Fonseca M, Izaurralde E (Sep 1999). "Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p". EMBO J 18 (15): 4332–47. doi:10.1093/emboj/18.15.4332. PMC 1171509. PMID 10428971. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171509. 
2. ^ ^{a b} "Entrez Gene: DDX19B DEAD (Asp-Glu-Ala-As) box polypeptide 19B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11269. 

Further reading

• Mattioni T, Hume CR, Konigorski S, et al. (1992). "A cDNA clone for a novel nuclear protein with DNA binding activity.". Chromosoma 101 (10): 618–24. doi:10.1007/BF00360539. PMID 1424986. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Yin L, Li J, Zhu H, et al. (2003). "Identification and characterization of a gene coding a novel isoform of DEAD-box protein.". Reprod. Fertil. Dev. 14 (3-4): 185–9. doi:10.1071/RD01028. PMID 12219940. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.