DAZAP2

DAZ associated protein 2
Identifiers
Symbols	DAZAP2; KIAA0058; MGC14319; MGC766; PRTB
External IDs	OMIM: 607431 MGI: 1344344 HomoloGene: 8038 GeneCards: DAZAP2 Gene
Gene Ontology Molecular function • protein binding • WW domain binding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9802	23994
Ensembl	ENSG00000183283	ENSMUSG00000000346
UniProt	Q15038	Q3ULN7
RefSeq (mRNA)	NM_001136264.1	NM_011873.2
RefSeq (protein)	NP_001129736.1	NP_036003.2
Location (UCSC)	Chr 12: 51.63 – 51.64 Mb	Chr 15: 100.44 – 100.45 Mb
PubMed search	[1]	[2]

DAZ-associated protein 2 is a protein that in humans is encoded by the DAZAP2 gene.^[1][2][3]

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region and is deleted in many azoospermic and severely oligospermic men. It is thought that the Y chromosomal DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL.^[3]

Interactions

DAZAP2 has been shown to interact with DAZ1.^[1]

References

1. ^ ^{a b} Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (Aug 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750. 
2. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044. 
3. ^ ^{a b} "Entrez Gene: DAZAP2 DAZ associated protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9802. 

Further reading

• Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP (2001). "Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates.". J. Biol. Chem. 276 (28): 26324–31. doi:10.1074/jbc.M101205200. PMID 11342538. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Cohen-Barak O, Yi Z, Hagiwara N, et al. (2004). "Sox6 regulation of cardiac myocyte development.". Nucleic Acids Res. 31 (20): 5941–8. doi:10.1093/nar/gkg807. PMC 219484. PMID 14530442. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=219484. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Shi Y, Luo S, Peng J, et al. (2005). "The structure, expression and function prediction of DAZAP2, a down-regulated gene in multiple myeloma.". Genomics Proteomics Bioinformatics 2 (1): 47–54. PMID 15629043. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Shi YW, Shen R, Ren W, et al. (2007). "Molecular features and expression of DAZAP2 in human multiple myeloma.". Chin. Med. J. 120 (19): 1659–65. PMID 17935665.