PCGF6

PCGF6
Polycomb group ring finger 6

PDB rendering based on 2djb.
Identifiers
Symbols PCGF6; MBLR; MGC15678; MGC17541; RNF134
External IDs OMIM607816 MGI1918291 HomoloGene12378 GeneCards: PCGF6 Gene
Orthologs
Species Human Mouse
Entrez 84108 71041
Ensembl ENSG00000156374 ENSMUSG00000025050
UniProt Q9BYE7 Q3V1H7
RefSeq (mRNA) NM_001011663.1 NM_027654.2
RefSeq (protein) NP_001011663.1 NP_081930.1
Location (UCSC) Chr 10:
105.06 – 105.11 Mb
Chr 19:
47.11 – 47.13 Mb
PubMed search [1] [2]

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.[1][2]

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References

  1. ^ Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation". Genes Cells 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. PMID 12167161. 
  2. ^ a b "Entrez Gene: PCGF6 polycomb group ring finger 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84108. 

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  • RING finger domain — Pfam box Symbol = zf C3HC4 Name = Zinc finger, C3HC4 type (RING finger) width = caption = Pfam= PF00097 InterPro= IPR001841 SMART= PROSITE= PDOC00449 SCOP = 1chc TCDB = OPM family= OPM protein= PDB=PDB3|1jm7A:24 64 PDB3|1rmd :290 328 PDB3|1bor… …   Wikipedia

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