PDCD5

Programmed cell death 5
PDB rendering based on 2cru.
Available structures PDB 1YYB, 2CRU, 2K6B
Identifiers
Symbols	PDCD5; FLJ42784; MGC9294; TFAR19
External IDs	OMIM: 604583 MGI: 1913538 HomoloGene: 10506 GeneCards: PDCD5 Gene
Gene Ontology Molecular function • DNA binding Cellular component • nucleus • cytoplasm Biological process • apoptosis • induction of apoptosis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9141	56330
Ensembl	ENSG00000105185	ENSMUSG00000030417
UniProt	O14737	Q564F6
RefSeq (mRNA)	NM_004708	NM_019746.4
RefSeq (protein)	NP_004699	NP_062720.1
Location (UCSC)	Chr 19: 33.07 – 33.08 Mb	Chr 7: 36.43 – 36.43 Mb
PubMed search	[1]	[2]

Programmed cell death protein 5 is a protein that in humans is encoded by the PDCD5 gene.^[1][2]

This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm. Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.^[2]

References

1. ^ Liu H, Wang Y, Zhang Y, Song Q, Di C, Chen G, Tang J, Ma D (Feb 1999). "TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal". Biochem Biophys Res Commun 254 (1): 203–10. doi:10.1006/bbrc.1998.9893. PMID 9920759. 
2. ^ ^{a b} "Entrez Gene: PDCD5 programmed cell death 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9141. 

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Chen Y, Sun R, Han W et al. (2002). "Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?". FEBS Lett. 509 (2): 191–6. doi:10.1016/S0014-5793(01)03062-9. PMID 11741587. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Xu M, Cheng N, Gui L et al. (2004). "The 5'-upstream region of human programmed cell death 5 gene contains a highly active TATA-less promoter that is up-regulated by etoposide". Gene 329: 39–49. doi:10.1016/j.gene.2003.12.025. PMID 15033527. 
• Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Liu D, Yao H, Chen Y et al. (2006). "The N-terminal 26-residue fragment of human programmed cell death 5 protein can form a stable α-helix having unique electrostatic potential character". Biochem. J. 392 (Pt 1): 47–54. doi:10.1042/BJ20050688. PMC 1317663. PMID 16083422. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1317663. 
• Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
• Ma X, Ruan G, Wang Y et al. (2006). "Two single-nucleotide polymorphisms with linkage disequilibrium in the human programmed cell death 5 gene 5' regulatory region affect promoter activity and the susceptibility of chronic myelogenous leukemia in Chinese population". Clin. Cancer Res. 11 (24 Pt 1): 8592–9. doi:10.1158/1078-0432.CCR-05-0039. PMID 16361542. 
• Yang YH, Zhao M, Li WM et al. (2007). "Expression of programmed cell death 5 gene involves in regulation of apoptosis in gastric tumor cells". Apoptosis 11 (6): 993–1001. doi:10.1007/s10495-006-6714-6. PMID 16547588. 
• Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Wang N, Lu HS, Guan ZP et al. (2007). "Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis". Apoptosis 12 (8): 1433–41. doi:10.1007/s10495-007-0070-z. PMID 17468978.