- TUB (gene)
Tubby homolog (mouse), also known as TUB, is a human
gene .cite web | title = Entrez Gene: TUB tubby homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7275| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: TUB tubby homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7275| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ikeda A, Nishina PM, Naggert JK |title=The tubby-like proteins, a family with roles in neuronal development and function. |journal=J. Cell. Sci. |volume=115 |issue= Pt 1 |pages= 9–14 |year= 2002 |pmid= 11801719 |doi=
*cite journal | author=Jones JM, Meisler MH, Seldin MF, "et al." |title=Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. |journal=Genomics |volume=14 |issue= 1 |pages= 197–9 |year= 1992 |pmid= 1358794 |doi=
*cite journal | author=Kleyn PW, Fan W, Kovats SG, "et al." |title=Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. |journal=Cell |volume=85 |issue= 2 |pages= 281–90 |year= 1996 |pmid= 8612280 |doi=
*cite journal | author=North MA, Naggert JK, Yan Y, "et al." |title=Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 3128–33 |year= 1997 |pmid= 9096357 |doi=
*cite journal | author=Kapeller R, Moriarty A, Strauss A, "et al." |title=Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24980–6 |year= 1999 |pmid= 10455176 |doi=
*cite journal | author=Boggon TJ, Shan WS, Santagata S, "et al." |title=Implication of tubby proteins as transcription factors by structure-based functional analysis. |journal=Science |volume=286 |issue= 5447 |pages= 2119–25 |year= 1999 |pmid= 10591637 |doi=
*cite journal | author=He W, Ikeda S, Bronson RT, "et al." |title=GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. |journal=Brain Res. Mol. Brain Res. |volume=81 |issue= 1-2 |pages= 109–17 |year= 2001 |pmid= 11000483 |doi=
*cite journal | author=Santagata S, Boggon TJ, Baird CL, "et al." |title=G-protein signaling through tubby proteins. |journal=Science |volume=292 |issue= 5524 |pages= 2041–50 |year= 2001 |pmid= 11375483 |doi= 10.1126/science.1061233
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, "et al." |title=Identification of TUB as a novel candidate gene influencing body weight in humans. |journal=Diabetes |volume=55 |issue= 2 |pages= 385–9 |year= 2006 |pmid= 16443771 |doi=
*cite journal | author=Giannaccini G, Giusti L, Santini F, "et al." |title=Tubby protein in human lymphocytes from normal weight and obese subjects. |journal=Clin. Biochem. |volume=40 |issue= 11 |pages= 806–9 |year= 2007 |pmid= 17498679 |doi= 10.1016/j.clinbiochem.2007.03.020PBB_Controls
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