RYK (gene)

RYK receptor-like tyrosine kinase, also known as RYK, is a human gene.cite web | title = Entrez Gene: RYK RYK receptor-like tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6259| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.cite web | title = Entrez Gene: RYK RYK receptor-like tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6259| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Partanen J, Mäkelä TP, Alitalo R, "et al." |title=Putative tyrosine kinases expressed in K-562 human leukemia cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8913–7 |year= 1991 |pmid= 2247464 |doi=
*cite journal | author=Gough NM, Rakar S, Hovens CM, Wilks A |title=Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK. |journal=Mamm. Genome |volume=6 |issue= 4 |pages= 255–6 |year= 1995 |pmid= 7613029 |doi=
*cite journal | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=
*cite journal | author=Stacker SA, Hovens CM, Vitali A, "et al." |title=Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK). |journal=Oncogene |volume=8 |issue= 5 |pages= 1347–56 |year= 1993 |pmid= 8386829 |doi=
*cite journal | author=Tamagnone L, Partanen J, Armstrong E, "et al." |title=The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain. |journal=Oncogene |volume=8 |issue= 7 |pages= 2009–14 |year= 1993 |pmid= 8390040 |doi=
*cite journal | author=Wang XC, Katso R, Butler R, "et al." |title=H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer. |journal=Mol. Med. |volume=2 |issue= 2 |pages= 189–203 |year= 1996 |pmid= 8726462 |doi=
*cite journal | author=Katso RM, Russell RB, Ganesan TS |title=Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6427–40 |year= 1999 |pmid= 10454588 |doi=
*cite journal | author=Trivier E, Ganesan TS |title=RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23037–43 |year= 2002 |pmid= 11956217 |doi= 10.1074/jbc.M202486200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Lu W, Yamamoto V, Ortega B, Baltimore D |title=Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. |journal=Cell |volume=119 |issue= 1 |pages= 97–108 |year= 2004 |pmid= 15454084 |doi= 10.1016/j.cell.2004.09.019
*cite journal | author=Watanabe A, Akita S, Tin NT, "et al." |title=A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. |journal=Cleft Palate Craniofac. J. |volume=43 |issue= 3 |pages= 310–6 |year= 2006 |pmid= 16681403 |doi= 10.1597/04-145R1.1
*cite journal | author=Szafranski K, Schindler S, Taudien S, "et al." |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |journal= |volume=8 |issue= 8 |pages= R154 |year= |pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154

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