AK2

Adenylate kinase 2, also known as AK2, is a human gene.cite web | title = Entrez Gene: AK2 adenylate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=204| accessdate = ]

PBB_Summary
section_title =
summary_text = Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Two transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: AK2 adenylate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=204| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Pope SN, Lee IR |title=Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. |journal=J. Steroid Biochem. Mol. Biol. |volume=94 |issue= 1-3 |pages= 203–8 |year= 2005 |pmid= 15862967 |doi= 10.1016/j.jsbmb.2005.01.007
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Köhler C, Gahm A, Noma T, "et al." |title=Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. |journal=FEBS Lett. |volume=447 |issue= 1 |pages= 10–2 |year= 1999 |pmid= 10218571 |doi=
*cite journal | author=Lee Y, Kim JW, Lee SM, "et al." |title=Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. |journal=J. Biochem. |volume=123 |issue= 1 |pages= 47–54 |year= 1998 |pmid= 9504408 |doi=
*cite journal | author=Noma T, Song S, Yoon YS, "et al." |title=cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2. |journal=Biochim. Biophys. Acta |volume=1395 |issue= 1 |pages= 34–9 |year= 1998 |pmid= 9434148 |doi=
*cite journal | author=Lee Y, Kim JW, Lee IA, "et al." |title=Cloning and characterization of cDNA for human adenylate kinase 2A. |journal=Biochem. Mol. Biol. Int. |volume=39 |issue= 4 |pages= 833–42 |year= 1997 |pmid= 8843353 |doi=
*cite journal | author=Carritt B, King J, Welch HM |title=Gene order and localization of enzyme loci on the short arm of chromosome 1. |journal=Ann. Hum. Genet. |volume=46 |issue= Pt 4 |pages= 329–35 |year= 1983 |pmid= 6961883 |doi=
*cite journal | author=Hamada M, Sumida M, Okuda H, "et al." |title=Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne dystrophic serum aberrant adenylate kinase. |journal=J. Biol. Chem. |volume=257 |issue= 21 |pages= 13120–8 |year= 1982 |pmid= 6182143 |doi=
*cite journal | author=Bruns GA, Regina VM |title=Adenylate kinase 2, a mitochondrial enzyme. |journal=Biochem. Genet. |volume=15 |issue= 5-6 |pages= 477–86 |year= 1977 |pmid= 195572 |doi=

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