CXXC1

CXXC finger protein 1
Identifiers
Symbols	CXXC1; 2410002I16Rik; 5830420C16Rik; CFP1; CGBP; HsT2645; PCCX1; PHF18; SPP1; ZCGPC1; hCGBP
External IDs	OMIM: 609150 MGI: 1921572 HomoloGene: 32221 GeneCards: CXXC1 Gene
Gene Ontology Molecular function • DNA binding • protein binding • zinc ion binding • histone methyltransferase activity (H3-K4 specific) • unmethylated CpG binding • metal ion binding Cellular component • nucleus • nuclear speck • histone methyltransferase complex • Set1C/COMPASS complex Biological process • regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • histone H3-K4 methylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	30827	74322
Ensembl	ENSG00000154832	ENSMUSG00000024560
UniProt	Q9P0U4	Q3UIZ4
RefSeq (mRNA)	NM_001101654.1	NM_028868.3
RefSeq (protein)	NP_001095124.1	NP_083144.1
Location (UCSC)	Chr 18: 47.81 – 47.81 Mb	Chr 18: 74.38 – 74.38 Mb
PubMed search	[1]	[2]

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.^[1][2][3]

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.^[2]

References

1. ^ Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (Jun 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochem Biophys Res Commun 271 (2): 305–310. doi:10.1006/bbrc.2000.2614. PMID 10799292. 
2. ^ ^{a b} Voo KS, Carlone DL, Jacobsen BM, Flodin A, Skalnik DG (Mar 2000). "Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1". Mol Cell Biol 20 (6): 2108–2121. doi:10.1128/MCB.20.6.2108-2121.2000. PMC 110827. PMID 10688657. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110827. 
3. ^ "Entrez Gene: CXXC1 CXXC finger 1 (PHD domain)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30827. 

Further reading

• Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072. 
• Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732. 
• Lee JH, Voo KS, Skalnik DG (2002). "Identification and characterization of the DNA binding domain of CpG-binding protein". J. Biol. Chem. 276 (48): 44669–44676. doi:10.1074/jbc.M107179200. PMID 11572867. 
• Carlone DL, Skalnik DG (2001). "CpG binding protein is crucial for early embryonic development". Mol. Cell. Biol. 21 (22): 7601–7606. doi:10.1128/MCB.21.22.7601-7606.2001. PMC 99931. PMID 11604496. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99931. 
• Lee JH, Skalnik DG (2003). "CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals". J. Biol. Chem. 277 (44): 42259–42267. doi:10.1074/jbc.M205054200. PMID 12200428. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Barrios-Rodiles M, Brown KR, Ozdamar B et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153. 
• Lee JH, Skalnik DG (2006). "CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex". J. Biol. Chem. 280 (50): 41725–41731. doi:10.1074/jbc.M508312200. PMID 16253997. 
• Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Young SR, Skalnik DG (2007). "CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line". DNA Cell Biol. 26 (2): 80–90. doi:10.1089/dna.2006.0535. PMID 17328666.