NUPL2

Nucleoporin like 2
Identifiers
Symbols	NUPL2; CG1; NLP-1; NLP_1; hCG1
External IDs	MGI: 2387631 HomoloGene: 40573 GeneCards: NUPL2 Gene
Gene Ontology Molecular function • nucleic acid binding • nuclear export signal receptor activity • zinc ion binding • metal ion binding Cellular component • nucleus • nuclear pore • cytosol • cytosol • membrane • nuclear membrane Biological process • carbohydrate metabolic process • protein export from nucleus • hexose transport • regulation of glucose transport • protein transport • glucose transport • viral reproduction • mRNA transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11097	231042
Ensembl	ENSG00000136243	ENSMUSG00000048439
UniProt	O15504	Q8CIC2
RefSeq (mRNA)	NM_007342	NM_153092.4
RefSeq (protein)	NP_031368	NP_694732.3
Location (UCSC)	Chr 7: 23.22 – 23.24 Mb	Chr 5: 23.67 – 23.69 Mb
PubMed search	[1]	[2]

Nucleoporin-like 2 is a protein that in humans is encoded by the NUPL2 gene.^[1][2][3]

References

1. ^ Farjot G, Sergeant A, Mikaelian I (Jul 1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J Biol Chem 274 (24): 17309–17317. doi:10.1074/jbc.274.24.17309. PMID 10358091. 
2. ^ Van Laer L, Van Camp G, van Zuijlen D, Green ED, Verstreken M, Schatteman I, Van de Heyning P, Balemans W, Coucke P, Greinwald JH, Smith RJ, Huizing E, Willems P (Mar 1998). "Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea". Eur J Hum Genet 5 (6): 397–405. PMID 9450185. 
3. ^ "Entrez Gene: NUPL2 nucleoporin like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11097. 

Further reading

• Fouchier RA, Meyer BE, Simon JH et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex". J. Virol. 72 (7): 6004–13. PMC 110405. PMID 9621063. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110405. 
• Katahira J, Strässer K, Podtelejnikov A et al. (1999). "The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human". EMBO J. 18 (9): 2593–2609. doi:10.1093/emboj/18.9.2593. PMC 1171339. PMID 10228171. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171339. 
• Strahm Y, Fahrenkrog B, Zenklusen D et al. (1999). "The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p". EMBO J. 18 (20): 5761–5777. doi:10.1093/emboj/18.20.5761. PMC 1171643. PMID 10610322. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171643. 
• de Noronha CM, Sherman MP, Lin HW et al. (2001). "Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr". Science 294 (5544): 1105–1108. doi:10.1126/science.1063957. PMID 11691994. 
• Le Rouzic E, Mousnier A, Rustum C et al. (2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–45098. doi:10.1074/jbc.M207439200. PMID 12228227. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Sasaki M, Takeda E, Takano K et al. (2005). "Molecular cloning and functional characterization of mouse Nxf family gene products". Genomics 85 (5): 641–653. doi:10.1016/j.ygeno.2005.01.003. PMID 15820316. 
• Kendirgi F, Rexer DJ, Alcázar-Román AR et al. (2006). "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA". Mol. Biol. Cell 16 (9): 4304–4315. doi:10.1091/mbc.E04-11-0998. PMC 1196339. PMID 16000379. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1196339. 
• Deniaud A, Brenner C, Kroemer G (2005). "Mitochondrial membrane permeabilization by HIV-1 Vpr". Mitochondrion 4 (2–3): 223–233. doi:10.1016/j.mito.2004.06.012. PMID 16120388.