RGS14

Regulator of G-protein signalling 14, also known as RGS14, is a human gene.cite web | title = Entrez Gene: RGS14 regulator of G-protein signalling 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10636| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: RGS14 regulator of G-protein signalling 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10636| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Snow BE, Antonio L, Suggs S, "et al." |title=Molecular cloning and expression analysis of rat Rgs12 and Rgs14. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 770–7 |year= 1997 |pmid= 9168931 |doi= 10.1006/bbrc.1997.6537
*cite journal | author=Traver S, Bidot C, Spassky N, "et al." |title=RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. |journal=Biochem. J. |volume=350 Pt 1 |issue= |pages= 19–29 |year= 2001 |pmid= 10926822 |doi=
*cite journal | author=Cho H, Kozasa T, Takekoshi K, "et al." |title=RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha- and G13alpha-mediated signaling pathways. |journal=Mol. Pharmacol. |volume=58 |issue= 3 |pages= 569–76 |year= 2000 |pmid= 10953050 |doi=
*cite journal | author=Kimple RJ, De Vries L, Tronchère H, "et al." |title=RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29275–81 |year= 2001 |pmid= 11387333 |doi= 10.1074/jbc.M103208200
*cite journal | author=Sierra DA, Gilbert DJ, Householder D, "et al." |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693
*cite journal | author=Kimple RJ, Kimple ME, Betts L, "et al." |title=Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. |journal=Nature |volume=416 |issue= 6883 |pages= 878–81 |year= 2002 |pmid= 11976690 |doi= 10.1038/416878a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hollinger S, Ramineni S, Hepler JR |title=Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. |journal=Biochemistry |volume=42 |issue= 3 |pages= 811–9 |year= 2003 |pmid= 12534294 |doi= 10.1021/bi026664y
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, "et al." |title=RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. |journal=Dev. Cell |volume=7 |issue= 5 |pages= 763–9 |year= 2004 |pmid= 15525537 |doi= 10.1016/j.devcel.2004.10.004
*cite journal | author=Martin-McCaffrey L, Willard FS, Pajak A, "et al." |title=RGS14 is a microtubule-associated protein. |journal=Cell Cycle |volume=4 |issue= 7 |pages= 953–60 |year= 2006 |pmid= 15917656 |doi=
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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