EXOC5

Exocyst complex component 5, also known as EXOC5, is a human gene.cite web | title = Entrez Gene: EXOC5 exocyst complex component 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10640| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.cite web | title = Entrez Gene: EXOC5 exocyst complex component 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10640| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hsu SC, TerBush D, Abraham M, Guo W |title=The exocyst complex in polarized exocytosis. |journal=Int. Rev. Cytol. |volume=233 |issue= |pages= 243–65 |year= 2004 |pmid= 15037366 |doi= 10.1016/S0074-7696(04)33006-8
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Guo W, Roth D, Gatti E, "et al." |title=Identification and characterization of homologues of the Exocyst component Sec10p. |journal=FEBS Lett. |volume=404 |issue= 2-3 |pages= 135–9 |year= 1997 |pmid= 9119050 |doi=
*cite journal | author=Kee Y, Yoo JS, Hazuka CD, "et al." |title=Subunit structure of the mammalian exocyst complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14438–43 |year= 1998 |pmid= 9405631 |doi=
*cite journal | author=Hsu SC, Hazuka CD, Roth R, "et al." |title=Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. |journal=Neuron |volume=20 |issue= 6 |pages= 1111–22 |year= 1998 |pmid= 9655500 |doi=
*cite journal | author=Brymora A, Valova VA, Larsen MR, "et al." |title=The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29792–7 |year= 2001 |pmid= 11406615 |doi= 10.1074/jbc.C100320200
*cite journal | author=Polzin A, Shipitsin M, Goi T, "et al." |title=Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1714–22 |year= 2002 |pmid= 11865051 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Inoue M, Chang L, Hwang J, "et al." |title=The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. |journal=Nature |volume=422 |issue= 6932 |pages= 629–33 |year= 2003 |pmid= 12687004 |doi= 10.1038/nature01533
*cite journal | author=Moskalenko S, Tong C, Rosse C, "et al." |title=Ral GTPases regulate exocyst assembly through dual subunit interactions. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51743–8 |year= 2004 |pmid= 14525976 |doi= 10.1074/jbc.M308702200
*cite journal | author=Prigent M, Dubois T, Raposo G, "et al." |title=ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. |journal=J. Cell Biol. |volume=163 |issue= 5 |pages= 1111–21 |year= 2004 |pmid= 14662749 |doi= 10.1083/jcb.200305029
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

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