Rnd2

Rnd2 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.cite journal |author=Ridley A. |year=2006 |title=Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking |journal=Trends Cell Biol |volume=16 |issue=10 |pages=522–9 |issn=0962-8924 |doi=10.1016/j.tcb.2006.08.006] . It is encoded by the gene RND2.cite web | title = Entrez Gene: RND2 Rho family GTPase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8153| accessdate = ]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998). [supplied by OMIM] cite web | title = Entrez Gene: RND1 Rho family GTPase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27289| accessdate = ]

PBB_Summary
section_title =
summary_text = This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.cite web | title = Entrez Gene: RND2 Rho family GTPase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8153| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chardin P |title=Small GTP-binding proteins of the ras family: a conserved functional mechanism? |journal=Cancer Cells |volume=3 |issue= 4 |pages= 117–26 |year= 1991 |pmid= 1909153 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Smith TM, Lee MK, Szabo CI, "et al." |title=Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. |journal=Genome Res. |volume=6 |issue= 11 |pages= 1029–49 |year= 1997 |pmid= 8938427 |doi=
*cite journal | author=Nobes CD, Lauritzen I, Mattei MG, "et al." |title=A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. |journal=J. Cell Biol. |volume=141 |issue= 1 |pages= 187–97 |year= 1998 |pmid= 9531558 |doi=
*cite journal | author=Tanaka H, Fujita H, Katoh H, "et al." |title=Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 349–53 |year= 2002 |pmid= 11931639 |doi= 10.1042/BJ20020062
*cite journal | author=Katoh H, Harada A, Mori K, Negishi M |title=Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 2952–64 |year= 2002 |pmid= 11940653 |doi=
*cite journal | author=Fujita H, Katoh H, Ishikawa Y, "et al." |title=Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45428–34 |year= 2003 |pmid= 12244061 |doi= 10.1074/jbc.M208090200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Naud N, Touré A, Liu J, "et al." |title=Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. |journal=Biochem. J. |volume=372 |issue= Pt 1 |pages= 105–12 |year= 2003 |pmid= 12590651 |doi= 10.1042/BJ20021652
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kim YS, Hori M, Yasuda K, Ozaki H |title=Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria. |journal=Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |volume=142 |issue= 4 |pages= 410–5 |year= 2006 |pmid= 16311049 |doi= 10.1016/j.cbpa.2005.08.028
*cite journal | author=Tanaka H, Katoh H, Negishi M |title=Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 10355–64 |year= 2006 |pmid= 16481321 |doi= 10.1074/jbc.M511314200

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