VPS4A

Vacuolar protein sorting 4 homolog A (S. cerevisiae), also known as VPS4A, is a human gene.cite web | title = Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27183| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.cite web | title = Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27183| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scheuring S, Bodor O, Röhricht RA, "et al." |title=Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking. |journal=Gene |volume=234 |issue= 1 |pages= 149–59 |year= 1999 |pmid= 10393249 |doi=
*cite journal | author=Bishop N, Woodman P |title=ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 227–39 |year= 2000 |pmid= 10637304 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Howard TL, Stauffer DR, Degnin CR, Hollenberg SM |title=CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. |journal=J. Cell. Sci. |volume=114 |issue= Pt 13 |pages= 2395–404 |year= 2002 |pmid= 11559748 |doi=
*cite journal | author=Scheuring S, Röhricht RA, Schöning-Burkhardt B, "et al." |title=Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. |journal=J. Mol. Biol. |volume=312 |issue= 3 |pages= 469–80 |year= 2001 |pmid= 11563910 |doi= 10.1006/jmbi.2001.4917
*cite journal | author=Tanaka H, Fujita H, Katoh H, "et al." |title=Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 349–53 |year= 2002 |pmid= 11931639 |doi= 10.1042/BJ20020062
*cite journal | author=Nara A, Mizushima N, Yamamoto A, "et al." |title=SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formation. |journal=Cell Struct. Funct. |volume=27 |issue= 1 |pages= 29–37 |year= 2002 |pmid= 11937716 |doi=
*cite journal | author=Chagnon P, Michaud J, Mitchell G, "et al." |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443–9 |year= 2003 |pmid= 12417987 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Beyer A, Scheuring S, Müller S, "et al." |title=Comparative sequence and expression analyses of four mammalian VPS4 genes. |journal=Gene |volume=305 |issue= 1 |pages= 47–59 |year= 2003 |pmid= 12594041 |doi=
*cite journal | author=Katoh K, Shibata H, Suzuki H, "et al." |title=The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39104–13 |year= 2003 |pmid= 12860994 |doi= 10.1074/jbc. M301604200
*cite journal | author=Strack B, Calistri A, Craig S, "et al." |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. |journal=Cell |volume=114 |issue= 6 |pages= 689–99 |year= 2003 |pmid= 14505569 |doi=
*cite journal | author=von Schwedler UK, Stuchell M, Müller B, "et al." |title=The protein network of HIV budding. |journal=Cell |volume=114 |issue= 6 |pages= 701–13 |year= 2003 |pmid= 14505570 |doi=
*cite journal | author=Sachse M, Strous GJ, Klumperman J |title=ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles. |journal=J. Cell. Sci. |volume=117 |issue= Pt 9 |pages= 1699–708 |year= 2004 |pmid= 15075231 |doi= 10.1242/jcs.00998
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lin Y, Kimpler LA, Naismith TV, "et al." |title=Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12799–809 |year= 2005 |pmid= 15632132 |doi= 10.1074/jbc. M413968200
*cite journal | author=Scott A, Gaspar J, Stuchell-Brereton MD, "et al." |title=Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 39 |pages= 13813–8 |year= 2005 |pmid= 16174732 |doi= 10.1073/pnas.0502165102
*cite journal | author=Tsang HT, Connell JW, Brown SE, "et al." |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003
*cite journal | author=Chen VY, Posada MM, Blazer LL, "et al." |title=The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug. |journal=Pharm. Res. |volume=23 |issue= 8 |pages= 1687–95 |year= 2007 |pmid= 16841193 |doi= 10.1007/s11095-006-9043-0
*cite journal | author=Lambert C, Döring T, Prange R |title=Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. |journal=J. Virol. |volume=81 |issue= 17 |pages= 9050–60 |year= 2007 |pmid= 17553870 |doi= 10.1128/JVI.00479-07

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