HDAC8

Histone deacetylase 8, also known as HDAC8, is a human gene.cite web | title = Entrez Gene: HDAC8 histone deacetylase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55869| accessdate = ]

PBB_Summary
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summary_text = Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.cite web | title = Entrez Gene: HDAC8 histone deacetylase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55869| accessdate = ]

ee also

* Histone deacetylase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Verdin E, Dequiedt F, Kasler HG |title=Class II histone deacetylases: versatile regulators. |journal=Trends Genet. |volume=19 |issue= 5 |pages= 286–93 |year= 2003 |pmid= 12711221 |doi=
*cite journal | author=Hu E, Chen Z, Fredrickson T, "et al." |title=Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15254–64 |year= 2000 |pmid= 10748112 |doi= 10.1074/jbc.M908988199
*cite journal | author=McDonell N, Ramser J, Francis F, "et al." |title=Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia. |journal=Genomics |volume=64 |issue= 3 |pages= 221–9 |year= 2000 |pmid= 10756090 |doi= 10.1006/geno.2000.6128
*cite journal | author=Van den Wyngaert I, de Vries W, Kremer A, "et al." |title=Cloning and characterization of human histone deacetylase 8. |journal=FEBS Lett. |volume=478 |issue= 1-2 |pages= 77–83 |year= 2000 |pmid= 10922473 |doi=
*cite journal | author=Buggy JJ, Sideris ML, Mak P, "et al." |title=Cloning and characterization of a novel human histone deacetylase, HDAC8. |journal=Biochem. J. |volume=350 Pt 1 |issue= |pages= 199–205 |year= 2001 |pmid= 10926844 |doi=
*cite journal | author=Amann JM, Nip J, Strom DK, "et al." |title=ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6470–83 |year= 2001 |pmid= 11533236 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Durst KL, Lutterbach B, Kummalue T, "et al." |title=The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 607–19 |year= 2003 |pmid= 12509458 |doi=
*cite journal | author=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200
*cite journal | author=Johnson JM, Castle J, Garrett-Engele P, "et al." |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100
*cite journal | author=Lee H, Rezai-Zadeh N, Seto E |title=Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 765–73 |year= 2004 |pmid= 14701748 |doi=
*cite journal | author=Vannini A, Volpari C, Filocamo G, "et al." |title=Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 42 |pages= 15064–9 |year= 2004 |pmid= 15477595 |doi= 10.1073/pnas.0404603101
*cite journal | author=Waltregny D, North B, Van Mellaert F, "et al." |title=Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells. |journal=European journal of histochemistry : EJH |volume=48 |issue= 3 |pages= 273–90 |year= 2005 |pmid= 15590418 |doi=
*cite journal | author=Waltregny D, Glénisson W, Tran SL, "et al." |title=Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. |journal=FASEB J. |volume=19 |issue= 8 |pages= 966–8 |year= 2006 |pmid= 15772115 |doi= 10.1096/fj.04-2303fje
*cite journal | author=Gantt SL, Gattis SG, Fierke CA |title=Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion. |journal=Biochemistry |volume=45 |issue= 19 |pages= 6170–8 |year= 2006 |pmid= 16681389 |doi= 10.1021/bi060212u
*cite journal | author=Lee H, Sengupta N, Villagra A, "et al." |title=Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5259–69 |year= 2006 |pmid= 16809764 |doi= 10.1128/MCB.01971-05
*cite journal | author=Vannini A, Volpari C, Gallinari P, "et al." |title=Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex. |journal=EMBO Rep. |volume=8 |issue= 9 |pages= 879–84 |year= 2007 |pmid= 17721440 |doi= 10.1038/sj.embor.7401047
*cite journal | author=Nakagawa M, Oda Y, Eguchi T, "et al." |title=Expression profile of class I histone deacetylases in human cancer tissues. |journal=Oncol. Rep. |volume=18 |issue= 4 |pages= 769–74 |year= 2007 |pmid= 17786334 |doi=

External links

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