Calcium-binding protein 1
- Calcium-binding protein 1
protein
Name=calcium binding protein 1
caption=
width=
HGNCid=1384
Symbol=CABP1
AltSymbols=
EntrezGene=9478
OMIM=605563
RefSeq=NM_001033677
UniProt=Q9NZU7
PDB=
ECnumber=
Chromosome=12
Arm=q
Band=24.31
LocusSupplementaryData=
Calcium-binding protein 1, also known as caldendrin and calbrain, is a calcium-binding protein discovered in 1999. [cite journal |author=Yamaguchi K, Yamaguchi F, Miyamoto O, Sugimoto K, Konishi R, Hatase O, Tokuda M |title=Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain |journal=J. Biol. Chem. |volume=274 |issue=6 |pages=3610–6 |year=1999 |pmid=9920909 |doi=] It has two EF hand motifs and is expressed in neuronal cells in such areas as hippocampus, habenular nucleus of the epithalamus, Purkinje cell layer of the cerebellum, and the amacrine cells and cone bipolar cells of the retina.]Cellular expression of caldendrin is restricted to the somato–dendritic compartment, with the exception of hypothalamus, where axonal labeling was detected. [cite journal |author=Bernstein HG, Seidenbecher CI, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR |title=Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain |journal=J. Histochem. Cytochem. |volume=51 |issue=8 |pages=1109–12 |year=2003 |pmid=12871994 |doi=] ]In schizophrenia, one study demonstrated a decrease in the number of CABP1-expressing cells, specifically in the left dorsolateral prefrontal cortex. This change, however, was compensated on a whole-brain scale by an increase in the protein levels. [cite journal |author=Bernstein HG, Sahin J, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR |title=A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia |journal=Schizophrenia Research |volume=96 |issue=1-3 |pages=246–56 |year=2007 |pmid=17719205 |doi=10.1016/j.schres.2007.05.038] ] References
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