ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4, also known as ST8SIA4, is a human gene.cite web | title = Entrez Gene: ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7903| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7903| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cohn JA, Noone PG, Jowell PS |title=Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. |journal=J. Investig. Med. |volume=50 |issue= 5 |pages= 247S–255S |year= 2002 |pmid= 12227654 |doi=
*cite journal | author=Nakayama J, Fukuda MN, Fredette B, "et al." |title=Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 15 |pages= 7031–5 |year= 1995 |pmid= 7624364 |doi=
*cite journal | author=Eckhardt M, Mühlenhoff M, Bethe A, "et al." |title=Molecular characterization of eukaryotic polysialyltransferase-1. |journal=Nature |volume=373 |issue= 6516 |pages= 715–8 |year= 1995 |pmid= 7854457 |doi= 10.1038/373715a0
*cite journal | author=Angata K, Nakayama J, Fredette B, "et al." |title=Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 7182–90 |year= 1997 |pmid= 9054414 |doi=
*cite journal | author=Angata K, Suzuki M, Fukuda M |title=Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28524–32 |year= 1998 |pmid= 9774483 |doi=
*cite journal | author=Close BE, Colley KJ |title=In vivo autopolysialylation and localization of the polysialyltransferases PST and STX. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34586–93 |year= 1999 |pmid= 9852130 |doi=
*cite journal | author=Close BE, Tao K, Colley KJ |title=Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4484–91 |year= 2000 |pmid= 10660622 |doi=
*cite journal | author=Angata K, Suzuki M, McAuliffe J, "et al." |title=Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18594–601 |year= 2000 |pmid= 10766765 |doi= 10.1074/jbc.M910204199
*cite journal | author=Angata K, Yen TY, El-Battari A, "et al." |title=Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15369–77 |year= 2001 |pmid= 11279095 |doi= 10.1074/jbc.M100576200
*cite journal | author=Close BE, Wilkinson JM, Bohrer TJ, "et al." |title=The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule. |journal=Glycobiology |volume=11 |issue= 11 |pages= 997–1008 |year= 2002 |pmid= 11744634 |doi=
*cite journal | author=Nałogowska-Głośnicka K, Łacka B, Zychma M, "et al." |title= [Relationship between SA gene Pst1 polymorphism and predisposition to H-gestosis] |journal=Pol. Arch. Med. Wewn. |volume=107 |issue= 1 |pages= 7–11 |year= 2002 |pmid= 12046348 |doi=
*cite journal | author=Angata K, Suzuki M, Fukuda M |title=ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36808–17 |year= 2002 |pmid= 12138100 |doi= 10.1074/jbc.M204632200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Beecken WD, Engl T, Ogbomo H, "et al." |title=Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells. |journal=Int. Immunopharmacol. |volume=5 |issue= 4 |pages= 757–69 |year= 2005 |pmid= 15710344 |doi= 10.1016/j.intimp.2004.12.009
*cite journal | author=Mendiratta SS, Sekulic N, Lavie A, Colley KJ |title=Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST. |journal=J. Biol. Chem. |volume=280 |issue= 37 |pages= 32340–8 |year= 2005 |pmid= 16027151 |doi= 10.1074/jbc.M506217200
*cite journal | author=Wang B, Hu H, Yu B |title=Molecular characterization of pig ST8Sia IV--a critical gene for the formation of neural cell adhesion molecule and its response to sialic acid supplement in piglets. |journal=Nutritional neuroscience |volume=9 |issue= 3-4 |pages= 147–54 |year= 2007 |pmid= 17176637 |doi=

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