NNMT

Nicotinamide N-methyltransferase
PDB rendering based on 2iip.
Available structures PDB 2iip
Identifiers
Symbols	NNMT;
External IDs	OMIM: 600008 MGI: 1099443 HomoloGene: 4496 GeneCards: NNMT Gene
EC number	2.1.1.1
Gene Ontology Molecular function • nicotinamide N-methyltransferase activity • methyltransferase activity • transferase activity • pyridine N-methyltransferase activity Cellular component • cytoplasm • cytosol Biological process • xenobiotic metabolic process • methylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4837	18113
Ensembl	ENSG00000166741	ENSMUSG00000032271
UniProt	P40261	Q9D9X3
RefSeq (mRNA)	NM_006169	NM_010924.2
RefSeq (protein)	NP_006160	NP_035054.1
Location (UCSC)	Chr 11: 114.13 – 114.18 Mb	Chr 9: 48.4 – 48.41 Mb
PubMed search	[1]	[2]

Nicotinamide N-methyltransferase is an enzyme that in humans is encoded by the NNMT gene.^[1][2]

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.^[2]

References

1. ^ Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum RM (Mar 1996). "Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization". Genomics 29 (3): 555–61. doi:10.1006/geno.1995.9966. PMID 8575745. 
2. ^ ^{a b} "Entrez Gene: NNMT nicotinamide N-methyltransferase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4837. 

Further reading

• Williams AC, Cartwright LS, Ramsden DB (2005). "Parkinson's disease: the first common neurological disease due to auto-intoxication?". QJM : monthly journal of the Association of Physicians 98 (3): 215–26. doi:10.1093/qjmed/hci027. PMID 15728403. 
• Sano A, Endo N, Takitani S (1992). "Fluorometric assay of rat tissue N-methyltransferases with nicotinamide and four isomeric methylnicotinamides.". Chem. Pharm. Bull. 40 (1): 153–6. PMID 1533573. 
• Aksoy S, Szumlanski CL, Weinshilboum RM (1994). "Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.". J. Biol. Chem. 269 (20): 14835–40. PMID 8182091. 
• Scheller T, Orgacka H, Szumlanski CL, Weinshilboum RM (1996). "Mouse liver nicotinamide N-methyltransferase pharmacogenetics: biochemical properties and variation in activity among inbred strains.". Pharmacogenetics 6 (1): 43–53. doi:10.1097/00008571-199602000-00003. PMID 8845860. 
• Smith ML, Burnett D, Bennett P, et al. (1998). "A direct correlation between nicotinamide N-methyltransferase activity and protein levels in human liver cytosol.". Biochim. Biophys. Acta 1442 (2–3): 238–44. PMID 9804963. 
• Yan L, Otterness DM, Weinshilboum RM (1999). "Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization". Pharmacogenetics 9 (3): 307–16. doi:10.1097/00008571-199906000-00005. PMID 10471062. 
• Hubbard MJ, McHugh NJ (2001). "Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping". Electrophoresis 21 (17): 3785–96. doi:10.1002/1522-2683(200011)21:17<3785::AID-ELPS3785>3.0.CO;2-2. PMID 11271497. 
• Parsons RB, Smith ML, Williams AC, et al. (2002). "Expression of nicotinamide N-methyltransferase (E.C. 2.1.1.1) in the Parkinsonian brain". J. Neuropathol. Exp. Neurol. 61 (2): 111–24. PMID 11853016. 
• Kassem HSh, Sangar V, Cowan R, et al. (2002). "A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer". Int. J. Cancer 101 (5): 454–60. doi:10.1002/ijc.10631. PMID 12216074. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Xu J, Capezzone M, Xu X, Hershman JM (2005). "Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells". Mol. Endocrinol. 19 (2): 527–39. doi:10.1210/me.2004-0215. PMID 15486044. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Souto JC, Blanco-Vaca F, Soria JM, et al. (2005). "A Genomewide Exploration Suggests a New Candidate Gene at Chromosome 11q23 as the Major Determinant of Plasma Homocysteine Levels: Results from the GAIT Project". Am. J. Hum. Genet. 76 (6): 925–33. doi:10.1086/430409. PMC 1196452. PMID 15849667. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1196452. 
• Roessler M, Rollinger W, Palme S, et al. (2005). "Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer". Clin. Cancer Res. 11 (18): 6550–7. doi:10.1158/1078-0432.CCR-05-0983. PMID 16166432. 
• Xu J, Hershman JM (2006). "Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells". Thyroid 16 (2): 151–60. doi:10.1089/thy.2006.16.151. PMID 16676400.