MCC (gene)

Mutated in colorectal cancers, also known as MCC, is a human gene.cite web | title = Entrez Gene: MCC mutated in colorectal cancers| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4163| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: MCC mutated in colorectal cancers| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4163| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lindgren V, Bryke CR, Ozcelik T, "et al." |title=Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis. |journal=Am. J. Hum. Genet. |volume=50 |issue= 5 |pages= 988–97 |year= 1992 |pmid= 1315124 |doi=
*cite journal | author=Nishisho I, Nakamura Y, Miyoshi Y, "et al." |title=Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. |journal=Science |volume=253 |issue= 5020 |pages= 665–9 |year= 1991 |pmid= 1651563 |doi=
*cite journal | author=Hoshino Y, Horikawa I, Oshimura M, Yuasa Y |title=Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity. |journal=Biochem. Biophys. Res. Commun. |volume=174 |issue= 1 |pages= 298–304 |year= 1991 |pmid= 1846539 |doi=
*cite journal | author=Kinzler KW, Nilbert MC, Vogelstein B, "et al." |title=Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. |journal=Science |volume=251 |issue= 4999 |pages= 1366–70 |year= 1991 |pmid= 1848370 |doi=
*cite journal | author=Curtis LJ, Bubb VJ, Gledhill S, "et al." |title=Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. |journal=Hum. Mol. Genet. |volume=3 |issue= 3 |pages= 443–6 |year= 1994 |pmid= 8012355 |doi=
*cite journal | author=Matsumine A, Senda T, Baeg GH, "et al." |title=MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10341–6 |year= 1996 |pmid= 8626604 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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