AP3M1

Adaptor-related protein complex 3, mu 1 subunit, also known as AP3M1, is a human gene.cite web | title = Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26985| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed.cite web | title = Entrez Gene: AP3M1 adaptor-related protein complex 3, mu 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26985| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Odorizzi G, Cowles CR, Emr SD |title=The AP-3 complex: a coat of many colours. |journal=Trends Cell Biol. |volume=8 |issue= 7 |pages= 282–8 |year= 1998 |pmid= 9714600 |doi=
*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Höning S, Sandoval IV, von Figura K |title=A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1304–14 |year= 1998 |pmid= 9482728 |doi= 10.1093/emboj/17.5.1304
*cite journal | author=Stephens DJ, Banting G |title=Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120. |journal=Biochem. J. |volume=335 ( Pt 3) |issue= |pages= 567–72 |year= 1998 |pmid= 9794796 |doi=
*cite journal | author=Dell'Angelica EC, Shotelersuk V, Aguilar RC, "et al." |title=Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 11–21 |year= 1999 |pmid= 10024875 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Craig HM, Reddy TR, Riggs NL, "et al." |title=Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. |journal=Virology |volume=271 |issue= 1 |pages= 9–17 |year= 2000 |pmid= 10814565 |doi= 10.1006/viro.2000.0277
*cite journal | author=Drake MT, Zhu Y, Kornfeld S |title=The assembly of AP-3 adaptor complex-containing clathrin-coated vesicles on synthetic liposomes. |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3723–36 |year= 2001 |pmid= 11071902 |doi=
*cite journal | author=Madrid R, Le Maout S, Barrault MB, "et al." |title=Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes. |journal=EMBO J. |volume=20 |issue= 24 |pages= 7008–21 |year= 2002 |pmid= 11742978 |doi= 10.1093/emboj/20.24.7008
*cite journal | author=Jia L, Young MF, Powell J, "et al." |title=Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. |journal=Genomics |volume=79 |issue= 1 |pages= 7–17 |year= 2002 |pmid= 11827452 |doi= 10.1006/geno.2001.6683
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Coleman SH, Van Damme N, Day JR, "et al." |title=Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. |journal=J. Virol. |volume=79 |issue= 4 |pages= 2066–78 |year= 2005 |pmid= 15681409 |doi= 10.1128/JVI.79.4.2066-2078.2005

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