CORT

Cortistatin, also known as CORT, is a human gene.cite web | title = Entrez Gene: CORT cortistatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1325| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene is a neuropeptide with strong structural similarity to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin.cite web | title = Entrez Gene: CORT cortistatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1325| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Spier AD, de Lecea L |title=Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. |journal=Brain Res. Brain Res. Rev. |volume=33 |issue= 2-3 |pages= 228–41 |year= 2001 |pmid= 11011067 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Fukusumi S, Kitada C, Takekawa S, "et al." |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157–63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252
*cite journal | author=de Lecea L, Ruiz-Lozano P, Danielson PE, "et al." |title=Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. |journal=Genomics |volume=42 |issue= 3 |pages= 499–506 |year= 1997 |pmid= 9205124 |doi= 10.1006/geno.1997.4763
*cite journal | author=Puebla L, Mouchantaf R, Sasi R, "et al." |title=Processing of rat preprocortistatin in mouse AtT-20 cells. |journal=J. Neurochem. |volume=73 |issue= 3 |pages= 1273–7 |year= 1999 |pmid= 10461921 |doi=
*cite journal | author=Ejeskär K, Abel F, Sjöberg R, "et al." |title=Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 62–6 |year= 2000 |pmid= 10894940 |doi=
*cite journal | author=Deghenghi R, Papotti M, Ghigo E, Muccioli G |title=Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. |journal=J. Endocrinol. Invest. |volume=24 |issue= 1 |pages= RC1–3 |year= 2001 |pmid= 11227737 |doi=
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Broglio F, Arvat E, Benso A, "et al." |title=Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 8 |pages= 3783–90 |year= 2002 |pmid= 12161511 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dalm VA, van Hagen PM, van Koetsveld PM, "et al." |title=Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 1 |pages= 270–6 |year= 2003 |pmid= 12519865 |doi=
*cite journal | author=Dalm VA, van Hagen PM, van Koetsveld PM, "et al." |title=Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 2 |pages= E344–53 |year= 2003 |pmid= 12684217 |doi= 10.1152/ajpendo.00048.2003
*cite journal | author=Robas N, Mead E, Fidock M |title=MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44400–4 |year= 2004 |pmid= 12915402 |doi= 10.1074/jbc.M302456200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Papotti M, Tarabra E, Allia E, "et al." |title=Presence of cortistatin in the human pancreas. |journal=J. Endocrinol. Invest. |volume=26 |issue= 8 |pages= RC15–8 |year= 2004 |pmid= 14669820 |doi=
*cite journal | author=Hernández C, Carrasco E, Casamitjana R, "et al." |title=Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects. |journal=Diabetes Care |volume=28 |issue= 8 |pages= 1941–7 |year= 2005 |pmid= 16043736 |doi=

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