COX4I1

Cytochrome c oxidase subunit IV isoform 1, also known as COX4I1, is a human gene.cite web | title = Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1327| accessdate = ]

PBB_Summary
section_title =
summary_text = Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.cite web | title = Entrez Gene: COX4I1 cytochrome c oxidase subunit IV isoform 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1327| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lithgow T |title=Targeting of proteins to mitochondria. |journal=FEBS Lett. |volume=476 |issue= 1-2 |pages= 22–6 |year= 2000 |pmid= 10878243 |doi=
*cite journal | author=Van Kuilenburg AB, Van Beeumen JJ, Demol H, "et al." |title=Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform. |journal=Biochim. Biophys. Acta |volume=1119 |issue= 2 |pages= 218–24 |year= 1992 |pmid= 1311608 |doi=
*cite journal | author=Lomax MI, Hewett-Emmett D, Yang TL, Grossman LI |title=Rapid evolution of the human gene for cytochrome c oxidase subunit IV. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5266–70 |year= 1992 |pmid= 1319058 |doi=
*cite journal | author=Lomax MI, Welch MD, Darras BT, "et al." |title=Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV. |journal=Gene |volume=86 |issue= 2 |pages= 209–16 |year= 1990 |pmid= 2157630 |doi=
*cite journal | author=Romero N, Marsac C, Fardeau M, "et al." |title=Immunohistochemical demonstration of fibre type-specific isozymes of cytochrome c oxidase in human skeletal muscle. |journal=Histochemistry |volume=94 |issue= 2 |pages= 211–5 |year= 1990 |pmid= 2162812 |doi=
*cite journal | author=Zeviani M, Nakagawa M, Herbert J, "et al." |title=Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase. |journal=Gene |volume=55 |issue= 2-3 |pages= 205–17 |year= 1987 |pmid= 2444497 |doi=
*cite journal | author=Bonne G, Seibel P, Possekel S, "et al." |title=Expression of human cytochrome c oxidase subunits during fetal development. |journal=Eur. J. Biochem. |volume=217 |issue= 3 |pages= 1099–107 |year= 1993 |pmid= 8223633 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Wu W, Goodman M, Lomax MI, Grossman LI |title=Molecular evolution of cytochrome c oxidase subunit IV: evidence for positive selection in simian primates. |journal=J. Mol. Evol. |volume=44 |issue= 5 |pages= 477–91 |year= 1997 |pmid= 9115172 |doi=
*cite journal | author=Bachman NJ, Wu W, Schmidt TR, "et al." |title=The 5' region of the COX4 gene contains a novel overlapping gene, NOC4. |journal=Mamm. Genome |volume=10 |issue= 5 |pages= 506–12 |year= 1999 |pmid= 10337626 |doi=
*cite journal | author=Hüttemann M, Kadenbach B, Grossman LI |title=Mammalian subunit IV isoforms of cytochrome c oxidase. |journal=Gene |volume=267 |issue= 1 |pages= 111–23 |year= 2001 |pmid= 11311561 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Williams SL, Valnot I, Rustin P, Taanman JW |title=Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7462–9 |year= 2004 |pmid= 14607829 |doi= 10.1074/jbc.M309232200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Fukuda R, Zhang H, Kim JW, "et al." |title=HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. |journal=Cell |volume=129 |issue= 1 |pages= 111–22 |year= 2007 |pmid= 17418790 |doi= 10.1016/j.cell.2007.01.047

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