BCOR

BCL6 co-repressor, also known as BCOR, is a human gene.cite web | title = Entrez Gene: BCOR BCL6 co-repressor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54880| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. At least two alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.cite web | title = Entrez Gene: BCOR BCL6 co-repressor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54880| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi=
*cite journal | author=Nagase T, Kikuno R, Nakayama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=
*cite journal | author=Tang TT, Dowbenko D, Jackson A, "et al." |title=The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 14255–65 |year= 2002 |pmid= 11777915 |doi= 10.1074/jbc.M110901200
*cite journal | author=Ng D, Hadley DW, Tifft CJ, Biesecker LG |title=Genetic heterogeneity of syndromic X-linked recessive microphthalmia-anophthalmia: is Lenz microphthalmia a single disorder? |journal=Am. J. Med. Genet. |volume=110 |issue= 4 |pages= 308–14 |year= 2002 |pmid= 12116202 |doi= 10.1002/ajmg.10484
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tomsig JL, Snyder SL, Creutz CE |title=Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10048–54 |year= 2003 |pmid= 12522145 |doi= 10.1074/jbc.M212632200
*cite journal | author=Srinivasan RS, de Erkenez AC, Hemenway CS |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. |journal=Oncogene |volume=22 |issue= 22 |pages= 3395–406 |year= 2003 |pmid= 12776190 |doi= 10.1038/sj.onc.1206361
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ng D, Thakker N, Corcoran CM, "et al." |title=Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. |journal=Nat. Genet. |volume=36 |issue= 4 |pages= 411–6 |year= 2004 |pmid= 15004558 |doi= 10.1038/ng1321
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Horn D, Chyrek M, Kleier S, "et al." |title=Novel mutations in BCOR in three patients with oculo-facio-cardio-dental syndrome, but none in Lenz microphthalmia syndrome. |journal=Eur. J. Hum. Genet. |volume=13 |issue= 5 |pages= 563–9 |year= 2005 |pmid= 15770227 |doi= 10.1038/sj.ejhg.5201391
*cite journal | author=Lee JA, Suh DC, Kang JE, "et al." |title=Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK. |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 28061–71 |year= 2005 |pmid= 15878880 |doi= 10.1074/jbc.M414134200
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ |title=Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. |journal=Mol. Cell. Biol. |volume=26 |issue= 18 |pages= 6880–9 |year= 2006 |pmid= 16943429 |doi= 10.1128/MCB.00630-06
*cite journal | author=Hilton EN, Manson FD, Urquhart JE, "et al." |title=Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination. |journal=Hum. Mol. Genet. |volume=16 |issue= 14 |pages= 1773–82 |year= 2007 |pmid= 17517692 |doi= 10.1093/hmg/ddm125

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes