HDAC6

Histone deacetylase 6, also known as HDAC6, is a human gene.

PBB_Summary
section_title =
summary_text = Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.cite web | title = Entrez Gene: HDAC6 histone deacetylase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10013| accessdate = ]

ee also

* Histone deacetylase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pazin MJ, Kadonaga JT |title=What's up and down with histone deacetylation and transcription? |journal=Cell |volume=89 |issue= 3 |pages= 325–8 |year= 1997 |pmid= 9150131 |doi=
*cite journal | author=Wolffe AP |title=Transcriptional control. Sinful repression. |journal=Nature |volume=387 |issue= 6628 |pages= 16–7 |year= 1997 |pmid= 9139815 |doi= 10.1038/387016a0
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Grozinger CM, Hassig CA, Schreiber SL |title=Three proteins define a class of human histone deacetylases related to yeast Hda1p. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4868–73 |year= 1999 |pmid= 10220385 |doi=
*cite journal | author=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi=
*cite journal | author=Mahlknecht U, Schnittger S, Landgraf F, "et al." |title=Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=93 |issue= 1-2 |pages= 135–6 |year= 2001 |pmid= 11474198 |doi=
*cite journal | author=Kao HY, Lee CH, Komarov A, "et al." |title=Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 187–93 |year= 2002 |pmid= 11677242 |doi= 10.1074/jbc.M108931200
*cite journal | author=Seigneurin-Berny D, Verdel A, Curtet S, "et al." |title=Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 8035–44 |year= 2001 |pmid= 11689694 |doi= 10.1128/MCB.21.23.8035-8044.2001
*cite journal | author=Tong JJ, Liu J, Bertos NR, Yang XJ |title=Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. |journal=Nucleic Acids Res. |volume=30 |issue= 5 |pages= 1114–23 |year= 2002 |pmid= 11861901 |doi=
*cite journal | author=Gao L, Cueto MA, Asselbergs F, Atadja P |title=Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25748–55 |year= 2002 |pmid= 11948178 |doi= 10.1074/jbc.M111871200
*cite journal | author=Hubbert C, Guardiola A, Shao R, "et al." |title=HDAC6 is a microtubule-associated deacetylase. |journal=Nature |volume=417 |issue= 6887 |pages= 455–8 |year= 2002 |pmid= 12024216 |doi= 10.1038/417455a
*cite journal | author=Kirsh O, Seeler JS, Pichler A, "et al." |title=The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. |journal=EMBO J. |volume=21 |issue= 11 |pages= 2682–91 |year= 2002 |pmid= 12032081 |doi= 10.1093/emboj/21.11.2682
*cite journal | author=Hook SS, Orian A, Cowley SM, Eisenman RN |title=Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13425–30 |year= 2002 |pmid= 12354939 |doi= 10.1073/pnas.172511699
*cite journal | author=Westendorf JJ, Zaidi SK, Cascino JE, "et al." |title=Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 7982–92 |year= 2002 |pmid= 12391164 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=North BJ, Marshall BL, Borra MT, "et al." |title=The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. |journal=Mol. Cell |volume=11 |issue= 2 |pages= 437–44 |year= 2003 |pmid= 12620231 |doi=
*cite journal | author=Voelter-Mahlknecht S, Mahlknecht U |title=Cloning and structural characterization of the human histone deacetylase 6 gene. |journal=Int. J. Mol. Med. |volume=12 |issue= 1 |pages= 87–93 |year= 2004 |pmid= 12792815 |doi=
*cite journal | author=Brush MH, Guardiola A, Connor JH, "et al." |title=Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7685–91 |year= 2004 |pmid= 14670976 |doi= 10.1074/jbc.M310997200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal |author=Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP |title=HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration |journal=Autophagy |volume=3 |issue=6 |pages=643–5 |date=Nov/Dec 2007 |pmid=17912024 |doi= |url=http://www.landesbioscience.com/journals/auto/abstract.php?id=5050 (Epub 2007 Sep 10)
*cite journal |author=Pandey UB, Nie Z, Batlevi Y, "et al" |title=HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS |journal=Nature |volume=447 |issue=7146 |pages=859–63 |date=June 14, 2007 |pmid=17568747 |doi=10.1038/nature05853 |url=

External links

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