NUCB1

Nucleobindin 1
PDB rendering based on 1snl.
Available structures PDB 1snl
Identifiers
Symbols	NUCB1; CALNUC; DKFZp686A15286; FLJ40471; NUC
External IDs	OMIM: 601323 MGI: 97388 HomoloGene: 4507 GeneCards: NUCB1 Gene
Gene Ontology Molecular function • DNA binding • calcium ion binding Cellular component • extracellular space • cytoplasm • ER-Golgi intermediate compartment • Golgi apparatus • microtubule cytoskeleton • membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4924	18220
Ensembl	ENSG00000104805	ENSMUSG00000030824
UniProt	Q02818	Q8BRD3
RefSeq (mRNA)	NM_006184	NM_008749
RefSeq (protein)	NP_006175	NP_032775
Location (UCSC)	Chr 19: 49.4 – 49.43 Mb	Chr 7: 52.75 – 52.77 Mb
PubMed search	[1]	[2]

Nucleobindin-1 is a protein that in humans is encoded by the NUCB1 gene.^[1][2]

References

1. ^ Miura K, Hirai M, Kanai Y, Kurosawa Y (Feb 1997). "Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4". Genomics 34 (2): 181–6. doi:10.1006/geno.1996.0263. PMID 8661046. 
2. ^ "Entrez Gene: NUCB1 nucleobindin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4924. 

Further reading

• Miura K, Titani K, Kurosawa Y, Kanai Y (1992). "Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure". Biochem. Biophys. Res. Commun. 187 (1): 375–80. doi:10.1016/S0006-291X(05)81503-7. PMID 1520323. 
• Mochizuki N, Hibi M, Kanai Y, Insel PA (1995). "Interaction of the protein nucleobindin with G alpha i2, as revealed by the yeast two-hybrid system". FEBS Lett. 373 (2): 155–8. doi:10.1016/0014-5793(95)01031-9. PMID 7589456. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Ballif BA, Mincek NV, Barratt JT et al. (1996). "Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5544–9. doi:10.1073/pnas.93.11.5544. PMC 39283. PMID 8643612. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39283. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Kubota T, Miyauchi M, Miura K et al. (1998). "Upregulation of nucleobindin expression in human-activated lymphocytes and non-Hodgkin's lymphoma". Pathol. Int. 48 (1): 22–8. doi:10.1111/j.1440-1827.1998.tb03823.x. PMID 9589460. 
• Lin P, Le-Niculescu H, Hofmeister R et al. (1998). "The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein". J. Cell Biol. 141 (7): 1515–27. doi:10.1083/jcb.141.7.1515. PMC 2132997. PMID 9647645. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132997. 
• Taniguchi N, Taniura H, Niinobe M et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798. 
• Weiss TS, Chamberlain CE, Takeda T et al. (2002). "Galpha i3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14961–6. doi:10.1073/pnas.261572098. PMC 64966. PMID 11752444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=64966. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• de Alba E, Tjandra N (2004). "Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc)". Biochemistry 43 (31): 10039–49. doi:10.1021/bi049310a. PMID 15287731. 
• Breuza L, Halbeisen R, Jenö P et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Chen Y, Lin P, Qiu S et al. (2007). "Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection". Int. J. Oncol. 30 (5): 1137–44. PMID 17390015. 
• Tsukumo Y, Tomida A, Kitahara O et al. (2007). "Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation". J. Biol. Chem. 282 (40): 29264–72. doi:10.1074/jbc.M705038200. PMID 17686766.