WIF1

WNT inhibitory factor 1, also known as WIF1, is a human gene.cite web | title = Entrez Gene: WIF1 WNT inhibitory factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11197| accessdate = ]

PBB_Summary
section_title =
summary_text = WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.cite web | title = Entrez Gene: WIF1 WNT inhibitory factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11197| accessdate = ]

References

Further reading

*cite journal | author=Malinauskas T |title=Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1 |journal=Lipids |volume=43 |issue= 3 |pages=227–30 |year= 2008 |pmid=18256869 |doi=10.1007/s11745-007-3144-3 PBB_Further_reading
citations =
*cite journal | author=Shepelev MV, Korobko EV, Korobko IV |title= [WIF1: perspectives of application in oncology] |journal=Mol. Gen. Mikrobiol. Virusol. |volume= |issue= 4 |pages= 3–7 |year= 2006 |pmid= 17094650 |doi=
*cite journal | author=Hsieh JC, Kodjabachian L, Rebbert ML, "et al." |title=A new secreted protein that binds to Wnt proteins and inhibits their activities. |journal=Nature |volume=398 |issue= 6726 |pages= 431–6 |year= 1999 |pmid= 10201374 |doi= 10.1038/18899
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Reguart N, He B, Xu Z, "et al." |title=Cloning and characterization of the promoter of human Wnt inhibitory factor-1. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 229–34 |year= 2004 |pmid= 15351726 |doi= 10.1016/j.bbrc.2004.08.075
*cite journal | author=Esufali S, Bapat B |title=Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. |journal=Oncogene |volume=23 |issue= 50 |pages= 8260–71 |year= 2004 |pmid= 15377999 |doi= 10.1038/sj.onc.1208007
*cite journal | author=Ohigashi T, Mizuno R, Nakashima J, "et al." |title=Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. |journal=Prostate |volume=62 |issue= 1 |pages= 61–8 |year= 2005 |pmid= 15389810 |doi= 10.1002/pros.20117
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Simon M, Grandage VL, Linch DC, Khwaja A |title=Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. |journal=Oncogene |volume=24 |issue= 14 |pages= 2410–20 |year= 2005 |pmid= 15735743 |doi= 10.1038/sj.onc.1208431
*cite journal | author=Taniguchi H, Yamamoto H, Hirata T, "et al." |title=Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. |journal=Oncogene |volume=24 |issue= 53 |pages= 7946–52 |year= 2005 |pmid= 16007117 |doi= 10.1038/sj.onc.1208910
*cite journal | author=Lin YC, You L, Xu Z, "et al." |title=Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 635–40 |year= 2006 |pmid= 16427602 |doi= 10.1016/j.bbrc.2005.12.220
*cite journal | author=Urakami S, Shiina H, Enokida H, "et al." |title=Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. |journal=Clin. Cancer Res. |volume=12 |issue= 2 |pages= 383–91 |year= 2006 |pmid= 16428476 |doi= 10.1158/1078-0432.CCR-05-1344
*cite journal | author=Liepinsh E, Bányai L, Patthy L, Otting G |title=NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. |journal=J. Mol. Biol. |volume=357 |issue= 3 |pages= 942–50 |year= 2006 |pmid= 16476441 |doi= 10.1016/j.jmb.2006.01.047
*cite journal | author=Batra S, Shi Y, Kuchenbecker KM, "et al." |title=Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 4 |pages= 1228–32 |year= 2006 |pmid= 16516163 |doi= 10.1016/j.bbrc.2006.02.084
*cite journal | author=Chim CS, Chan WW, Pang A, Kwong YL |title=Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. |journal=Leukemia |volume=20 |issue= 5 |pages= 907–9 |year= 2006 |pmid= 16525492 |doi= 10.1038/sj.leu.2404176
*cite journal | author=Urakami S, Shiina H, Enokida H, "et al." |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468
*cite journal | author=Milutinovic S, D'Alessio AC, Detich N, Szyf M |title=Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. |journal=Carcinogenesis |volume=28 |issue= 3 |pages= 560–71 |year= 2007 |pmid= 17012225 |doi= 10.1093/carcin/bgl167
*cite journal | author=Queimado L, Lopes CS, Reis AM |title=WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. |journal=Genes Chromosomes Cancer |volume=46 |issue= 3 |pages= 215–25 |year= 2007 |pmid= 17171686 |doi= 10.1002/gcc.20402
*cite journal | author=Chan SL, Cui Y, van Hasselt A, "et al." |title=The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. |journal=Lab. Invest. |volume=87 |issue= 7 |pages= 644–50 |year= 2007 |pmid= 17384664 |doi= 10.1038/labinvest.3700547

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