HYAL1

Hyaluronoglucosaminidase 1, also known as HYAL1, is a human gene.cite web | title = Entrez Gene: HYAL1 hyaluronoglucosaminidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3373| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: HYAL1 hyaluronoglucosaminidase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3373| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wei MH, Latif F, Bader S, "et al." |title=Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. |journal=Cancer Res. |volume=56 |issue= 7 |pages= 1487–92 |year= 1996 |pmid= 8603390 |doi=
*cite journal | author=Natowicz MR, Short MP, Wang Y, "et al." |title=Clinical and biochemical manifestations of hyaluronidase deficiency. |journal=N. Engl. J. Med. |volume=335 |issue= 14 |pages= 1029–33 |year= 1996 |pmid= 8793927 |doi=
*cite journal | author=Frost GI, Csóka AB, Wong T, "et al." |title=Purification, cloning, and expression of human plasma hyaluronidase. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 1 |pages= 10–5 |year= 1997 |pmid= 9223416 |doi=
*cite journal | author=Csóka AB, Frost GI, Wong T, "et al." |title=Purification and microsequencing of hyaluronidase isozymes from human urine. |journal=FEBS Lett. |volume=417 |issue= 3 |pages= 307–10 |year= 1998 |pmid= 9409739 |doi=
*cite journal | author=Csóka AB, Frost GI, Heng HH, "et al." |title=The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. |journal=Genomics |volume=48 |issue= 1 |pages= 63–70 |year= 1998 |pmid= 9503017 |doi=
*cite journal | author=Triggs-Raine B, Salo TJ, Zhang H, "et al." |title=Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6296–300 |year= 1999 |pmid= 10339581 |doi=
*cite journal | author=Frost GI, Mohapatra G, Wong TM, "et al." |title=HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. |journal=Oncogene |volume=19 |issue= 7 |pages= 870–7 |year= 2000 |pmid= 10702795 |doi= 10.1038/sj.onc.1203317
*cite journal | author=Shuttleworth TL, Wilson MD, Wicklow BA, "et al." |title=Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23008–18 |year= 2002 |pmid= 11929860 |doi= 10.1074/jbc.M108991200
*cite journal | author=Lokeshwar VB, Schroeder GL, Carey RI, "et al." |title=Regulation of hyaluronidase activity by alternative mRNA splicing. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33654–63 |year= 2002 |pmid= 12084718 |doi= 10.1074/jbc.M203821200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Junker N, Latini S, Petersen LN, Kristjansen PE |title=Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. |journal=Oncol. Rep. |volume=10 |issue= 3 |pages= 609–16 |year= 2003 |pmid= 12684632 |doi=
*cite journal | author=Franzmann EJ, Schroeder GL, Goodwin WJ, "et al." |title=Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. |journal=Int. J. Cancer |volume=106 |issue= 3 |pages= 438–45 |year= 2003 |pmid= 12845686 |doi= 10.1002/ijc.11252
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Muzny DM, Scherer SE, Kaul R, "et al." |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728
*cite journal | author=Christopoulos TA, Papageorgakopoulou N, Theocharis DA, "et al." |title=Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma. |journal=Biochim. Biophys. Acta |volume=1760 |issue= 7 |pages= 1039–45 |year= 2006 |pmid= 16713680 |doi= 10.1016/j.bbagen.2006.03.019
*cite journal | author=Lokeshwar VB, Estrella V, Lopez L, "et al." |title=HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. |journal=Cancer Res. |volume=66 |issue= 23 |pages= 11219–27 |year= 2007 |pmid= 17145867 |doi= 10.1158/0008-5472.CAN-06-1121
*cite journal | author=Hofinger ES, Spickenreither M, Oschmann J, "et al." |title=Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors. |journal=Glycobiology |volume=17 |issue= 4 |pages= 444–53 |year= 2007 |pmid= 17227790 |doi= 10.1093/glycob/cwm003
*cite journal | author=Nieuwdorp M, Holleman F, de Groot E, "et al." |title=Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis. |journal=Diabetologia |volume=50 |issue= 6 |pages= 1288–93 |year= 2007 |pmid= 17415544 |doi= 10.1007/s00125-007-0666-4
*cite journal | author=Bharadwaj AG, Rector K, Simpson MA |title=Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis. |journal=J. Biol. Chem. |volume=282 |issue= 28 |pages= 20561–72 |year= 2007 |pmid= 17502371 |doi= 10.1074/jbc.M702964200

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