HYAL3

Hyaluronoglucosaminidase 3, also known as HYAL3, is a human gene.cite web | title = Entrez Gene: HYAL3 hyaluronoglucosaminidase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8372| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.cite web | title = Entrez Gene: HYAL3 hyaluronoglucosaminidase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8372| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Muzny DM, Scherer SE, Kaul R, "et al." |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Junker N, Latini S, Petersen LN, Kristjansen PE |title=Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. |journal=Oncol. Rep. |volume=10 |issue= 3 |pages= 609-16 |year= 2003 |pmid= 12684632 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lokeshwar VB, Schroeder GL, Carey RI, "et al." |title=Regulation of hyaluronidase activity by alternative mRNA splicing. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33654-63 |year= 2002 |pmid= 12084718 |doi= 10.1074/jbc.M203821200
*cite journal | author=Shuttleworth TL, Wilson MD, Wicklow BA, "et al." |title=Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23008-18 |year= 2002 |pmid= 11929860 |doi= 10.1074/jbc.M108991200
*cite journal | author=Csóka AB, Scherer SW, Stern R |title=Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. |journal=Genomics |volume=60 |issue= 3 |pages= 356-61 |year= 1999 |pmid= 10493834 |doi= 10.1006/geno.1999.5876
*cite journal | author=Triggs-Raine B, Salo TJ, Zhang H, "et al." |title=Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6296-300 |year= 1999 |pmid= 10339581 |doi=

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