- EIF2S3
Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa, also known as EIF2S3, is a human
gene .cite web | title = Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968| accessdate = ] cite journal | author = Gaspar NJ, Kinzy TG, Scherer BJ, Hümbelin M, Hershey JW, Merrick WC | title = Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit | journal = J. Biol. Chem. | volume = 269 | issue = 5 | pages = 3415–22 | year = 1994 | month = February | pmid = 8106381 | url = http://www.jbc.org/cgi/content/abstract/269/5/3415 | issn = ] cite journal | author = Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM | title = Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution | journal = Hum. Mol. Genet. | volume = 7 | issue = 11 | pages = 1725–37 | year = 1998 | month = October | pmid = 9736774 | doi = 10.1093/hmg/7.11.1725 | url = | issn = ]Function
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of
protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma (this article), with the protein encoded by this gene representing the gamma subunit.ee also
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eIF2 References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ray MK, Chakraborty A, Datta B, "et al." |title=Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide. |journal=Biochemistry |volume=32 |issue= 19 |pages= 5151–9 |year= 1993 |pmid= 8098621 |doi=
*cite journal | author=Gaspar NJ, Kinzy TG, Scherer BJ, "et al." |title=Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. |journal=J. Biol. Chem. |volume=269 |issue= 5 |pages= 3415–22 |year= 1994 |pmid= 8106381 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Brand SR, Kobayashi R, Mathews MB |title=The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8388–95 |year= 1997 |pmid= 9079663 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ehrmann IE, Ellis PS, Mazeyrat S, "et al." |title=Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1725–37 |year= 1998 |pmid= 9736774 |doi=
*cite journal | author=Cai R, Carpick B, Chun RF, "et al." |title=HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms. |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 361–7 |year= 2000 |pmid= 10620360 |doi= 10.1006/abbi.1999.1583
*cite journal | author=Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R |title=Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 1011–8 |year= 2000 |pmid= 10648795 |doi=
*cite journal | author=Kruger M, Beger C, Li QX, "et al." |title=Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8566–71 |year= 2000 |pmid= 10900014 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Filippova GN, Cheng MK, Moore JM, "et al." |title=Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. |journal=Dev. Cell |volume=8 |issue= 1 |pages= 31–42 |year= 2005 |pmid= 15669143 |doi=
*cite journal | author=Marques AC, Dupanloup I, Vinckenbosch N, "et al." |title=Emergence of young human genes after a burst of retroposition in primates. |journal=PLoS Biol. |volume=3 |issue= 11 |pages= e357 |year= 2006 |pmid= 16201836 |doi= 10.1371/journal.pbio.0030357
*cite journal | author=Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV |title=Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1766–72 |year= 2006 |pmid= 16288713 |doi= 10.1016/j.bbrc.2005.10.150
*cite journal | author=Mikami S, Masutani M, Sonenberg N, "et al." |title=An efficient mammalian cell-free translation system supplemented with translation factors. |journal=Protein Expr. Purif. |volume=46 |issue= 2 |pages= 348–57 |year= 2006 |pmid= 16289705 |doi= 10.1016/j.pep.2005.09.021
*cite journal | author=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. |journal=Mol. Cell Proteomics |volume=6 |issue= 4 |pages= 575–88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134PBB_Controls
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